Sort   by:  
 Page size 
TranscriptomicsE-cadherin and EMT regulation by bHLH factors: a new role for the class I gene E2-2 (TCF4) and its comparison with E47.
Loss of expression of the cell-cell adhesion molecule E-cadherin is an essential event for epithelial-mesenchymal transition (EMT), a process that allows cell migration in the developing embryo and during tumour invasion. Transcriptional repression has emerged as the main mechanism responsible for E...
ORGANISM(S): Canis lupus familiaris 
2010-06-24 | E-GEOD-9145 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human HT29 colon cancer cells to investigate the role of Caveolin 1, E-Cadherin, Enolase 2 and PKCa on resistance to methotrexate
A summary of the work associated to these microarrays is the following:; Methotrexate (MTX) is one of the earliest cytotoxic drugs used in cancer therapy, and despite the isolation of multiple other folate antagonists, methotrexate maintains its significant role as a treatment for different types of...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-11440 | biostudies-arrayexpress
GenomicsEffect of CD5-2 on endothelial cells with or without VE-cadherin expression
Effect of CD5-2 on endothelial cells with or without VE-cadherin expression
PRJNA630680 | ENA
TranscriptomicsIdentification of novel tissue-specific transcription arising from E-cadherin/CDH1 intron2: a novel protein isoform increases gastric cancer cell invasion and angiogenesis.
E-cadherin, a protein encoded by the CDH1 gene is the dominant epithelial cell adhesion molecule playing a crucial role in epithelial tissue polarity and structural integrity. The progression of 90% or more carcinomas is believed to be mediated by disruption of normal E-cadherin expression, subcellu...
ORGANISM(S): Homo sapiens 
2012-08-01 | E-GEOD-32540 | biostudies-arrayexpress
TranscriptomicsEffect of CD5-2 on endothelial cells with or without VE-cadherin expression
Purpose: The goals of this study are to confirm whether CD5-2 works through VE-cadherin Methods: mRNA profiles of HUVEC and VE-cadherin-/- EC treated with either control or CD5-2 were generated by deep sequencing using Illumina Hiseq4000 platform and 150 bp paired-end reads were generated. Reference...
ORGANISM(S): Mus musculus Homo sapiens 
2020-05-07 | GSE149948 | GEO
TranscriptomicsHuman periodontal ligament fibroblasts (PdLFs) were treated with 1-nonadecene, a metabolite from radicular cysts, in comparison to the untreated and positive controls
Human PdLFs (iCell Bioscience, China) were treated with 1µM, 10µM, and 100µM 1-nonadecene (TCI, US-Japan). PdLFs were treated daily with fresh media containing 1-nonadecene for 2- and 6-days. Phorbol 12-myristate 13-acetate (PMA) (ab120297, Abcam, UK) at 1µM was used as an inflammatory inducer, a po...
ORGANISM(S): Homo sapiens 
2023-06-09 | E-MTAB-12931 | biostudies-arrayexpress
OtherThe N-cadherin interactome in primary cardiomyocytes
Low levels of Cdh2-BioID2 were expressed in mouse primary neonatal cardiomyocytes using an adenoviral expression system. Infected cells were treated with biotin for 24 hours before lysis. Biotinylated proteins were precipitated from lysates using streptavidin beads. Protein samples were in-gel tryps...
ORGANISM(S): Mus Musculus 
2019-01-23 | MSV000083356 | MassIVE
ProteomicsThe N-cadherin interactome in primary cardiomyocytes as defined by quantitative proximity proteomics
Low levels of Cdh2-BioID2 were expressed in mouse primary neonatal cardiomyocytes using an adenoviral expression system. Infected cells were treated with biotin for 24 hours before lysis. Biotinylated proteins were precipitated from lysates using streptavidin beads. Protein samples were in-gel tryps...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-01-24 | MSV000083362 | MassIVE
ProteomicsProteomic analysis of HCC-1954 and MCF-7 cell lines highlights crosstalk between αvβ1 integrin, E-cadherin and HER-2
Overexpression of human epidermal growth factor receptor 2 (HER-2) occurs in 20% of all breast cancer subtypes, those that present the worst prognostic outcome through a very invasive and aggressive tumour. HCC-1954 (HER-2+) is a highly invasive, metastatic cell line whereas MCF-7 is mildly aggressi...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD023876 | Pride
Hcc-1954 Membrane proteins Her-2 Breast cancer Mcf-7 Proteome 
TranscriptomicsEsophageal keratinocyte invasion after loss of E-cadherin and TGF receptor type II
Esophageal cancer is one of the deadliest cancers as patients present at late stages of disease. Frequent gene alterations include the loss of E-cadherin and TGFb receptor type II. The goal of this study was to establish a model of esophageal cancer by introducing dominant-negative mutants of E-cadh...
ORGANISM(S): Homo sapiens 
2013-11-12 | E-GEOD-19472 | biostudies-arrayexpress
Sort   by:  
 Page size