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ProteomicsProteomic analysis of HCC-1954 and MCF-7 cell lines highlights crosstalk between αvβ1 integrin, E-cadherin and HER-2
Overexpression of human epidermal growth factor receptor 2 (HER-2) occurs in 20% of all breast cancer subtypes, those that present the worst prognostic outcome through a very invasive and aggressive tumour. HCC-1954 (HER-2+) is a highly invasive, metastatic cell line whereas MCF-7 is mildly aggressi...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD023876 | Pride
Hcc-1954 Membrane proteins Her-2 Breast cancer Mcf-7 Proteome 
UnknownProteomic Analysis of HCC-1954 and MCF-7 Cell Lines Highlights Crosstalk between αv and β1 Integrins, E-Cadherin and HER-2.
Not available
S-EPMC9456615 | biostudies-literature
ProteomicsTumour-associated antigenic peptides are present in the HLA class I ligandome of cancer cell line derived extracellular vesicles.
The recent success of monoclonal antibody checkpoint inhibitor therapies that enhance the ability of CD8+ T cells to detect cancer-related antigenic peptides has refocused the need to fully understand the repertoire of peptides being presented to the immune system. Whilst the peptide ligandome prese...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD025345 | Pride
Cancer Extracellular vesicles T-cell epitopes Taa Hla class i ligandome Evs Tumour. Tumour-associated antigens 
GenomicsSMAD3 and SOX4 binding profiling in human breast cell lines
In order to identify genes co-bound by SOX4 and SMAD3 in the context of breast cancer, different breast cell lines (HMLEs, MDA-MB-231 or HCC-1954) were used. Due to low endogenous expression levels for SOX4 in HMLEs in untreated conditions, doxycycline-dependent SOX4 overexpression was obtained by t...
ORGANISM(S): Homo sapiens 
2018-06-11 | GSE104760 | GEO
TranscriptomicsmRNA-seq of HCC1954 siControl and siRNF40
The analysis of genes affected upon RNF40 knockdown in HCC1954 cells
ORGANISM(S): Homo sapiens 
2020-11-16 | E-MTAB-9234 | biostudies-arrayexpress
TranscriptomicsmRNA-seq of HCC1954 siControl and siUSP22
The analysis of genes affected upon USP22 kcnockdown in HCC1954 cells
ORGANISM(S): Homo sapiens 
2020-08-31 | E-MTAB-8256 | biostudies-arrayexpress
TranscriptomicsIdentification of circadian-related gene expression profiles in entrained MCF10A
Cancer cells have broken circadian clocks as compared to their normal tissue counterparts. Moreover, it has been shown in breast cancer that disruption of common circadian oscillations are associated to worse prognosis. Numerous studies focused at conical circadian genes in breast cancer cell lines ...
ORGANISM(S): Homo sapiens 
2016-04-01 | E-GEOD-76369 | biostudies-arrayexpress
TranscriptomicsIdentification of circadian-related gene expression profiles in entrained MCF7
Cancer cells have broken circadian clocks as compared to their normal tissue counterparts. Moreover, it has been shown in breast cancer that disruption of common circadian oscillations are associated to worse prognosis. Numerous studies focused at conical circadian genes in breast cancer cell lines ...
ORGANISM(S): Homo sapiens 
2016-04-01 | E-GEOD-76368 | biostudies-arrayexpress
UnknownMolecular mechanisms underlying TXNIP's anti-tumor role in breast cancer, including interaction with a novel, pro-tumor partner: CAST.
Not available
S-EPMC11965567 | biostudies-literature
ProteomicsDiscovery and pharmacological evaluation of STEAP4 as a novel target for HER2 overexpressing Breast cancer
The HER2 overexpressing and the Triple Negative Breast Cancer forms (TNBC) remain the most aggressive subtypes of BC with poor prognosis, frequent disease relapse and metastasis. In this study the aim was to identify key membrane-associated proteins which are overexpressed in these aggressive BC sub...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD021819 | Pride
Breast cacner Therapeutic targets Human Steap4 Orbitrap Her2 
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