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TranscriptomicsGene and pathways affected by CAG-repeat RNA-based toxicity in Drosophila
Spinocerebellar ataxia type 3 (SCA3) is one of the polyglutamine (polyQ) diseases, which are caused by a CAG repeat expansion within the coding region of the associated genes. The CAG repeat specifies glutamine, and the expanded polyQ domain with mutation confers dominant toxicity on the protein. Tr...
ORGANISM(S): Drosophila melanogaster 
2011-11-22 | E-GEOD-31875 | biostudies-arrayexpress
TranscriptomicsContinuous analysis captures cellular states that reflect dominant effects of the HTT CAG repeat in human lymphoblastoid cell lines.
In Huntington’s disease (HD), expanded HTT CAG repeat length correlates strongly with age at motor onset, indicating that it determines the rate of the disease process leading to diagnostic clinical manifestations. Similarly, in normal individuals, HTT CAG repeat length is correlated with biochemica...
ORGANISM(S): Homo sapiens 
2013-05-03 | E-GEOD-34721 | biostudies-arrayexpress
GenomicsTranscriptome analysis of CD229 OE (CAG-OE) and WT(CAG-WT) in CAG
Transcriptome analysis of CD229 OE (CAG-OE) and WT(CAG-WT) in CAG
PRJNA818871 | ENA
TranscriptomicsCag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection.
TC1: gastric epithelial (AGS) cells infected with wild type H. pylori (G27) and isogenic mutants in cagA and vacA for 0, 0.5, 3, 6, and 12 hours. Total RNA was used to make single stranded Cy5 labelled probe and compared to Cy3 labelled probe from uninfected AGS cells. Hybridizations of G27 (trial ...
ORGANISM(S): Homo sapiens 
2005-11-03 | E-GEOD-3556 | biostudies-arrayexpress
ProteomicsProteome profiling of an isogenic CAG allelic panel of Huntington disease hESCs and NPCs
Whole proteome profiling and quantification was performed on an isogenic Huntington disease (IsoHD) human embryonic stem cell (hESC) allelic panel. The IsoHD hESCs harbour 30, 45, 65 and 81 CAG repeats in the first exon of HTT. Whole proteome quantification was also performed on neural progenitor ce...
ORGANISM(S): Homo Sapiens (human) 
2019-02-14 | PXD006585 | JPOST Repository
TranscriptomicsMicroarray gene expression data from Hdh knock-out, wild-type and knock-in embryonic stem cells
Huntington's disease (HD) features a unique disease-initiating mechanism hypothesized to entail an impact of the CAG repeat encoded polyglutamine region on the full-length huntingtin protein, with dominant effects that are continuous with CAG size, in a simple gain of function. To evaluate these pre...
ORGANISM(S): Mus musculus 
2011-05-04 | E-GEOD-26001 | biostudies-arrayexpress
GenomicsCupriavidus alkaliphilus strain:CAG-122
Cupriavidus alkaliphilus CAG-122 genome sequencing
PRJNA439955 | ENA
TranscriptomicsTranscriptome profiling in knock-in mouse models of Huntington's disease [AllelicSeries_6month_TissueSurvey_mRNA]
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that is characterized by motor, cognitive, and psychiatric alterations. The mutation responsible for this disease is an abnormally expanded and unstable CAG repeat within the coding region of the gene encoding huntingtin (...
ORGANISM(S): Mus musculus 
2016-02-15 | E-GEOD-65775 | biostudies-arrayexpress
GenomicsCACNA1A CAG repeat sequencing in SCA6 patients
CACNA1A CAG repeat sequencing in SCA6 patients
PRJEB110442 | ENA
ProteomicstRNA-Leu(CAG) gene is conserved in most Saccharomycopsis yeast species but is non-essential and does not compete with tRNA-Ser(CAG) in translation Dataset 2B; S. capsularis Y-17639 tRNA-Leu(CAG) deletion Sporulation condition
In the yeast genera Saccharomycopsis and Ascoidea, nuclear genes use a non-standard genetic code in which CUG codons are translated as serine instead of leucine, due to the presence of a tRNA-Ser with the unusual anticodon CAG. However, some species in this ‘CUG-Ser2’ clade also contain an ancestral...
ORGANISM(S): Saccharomycopsis capsularis 
2024-10-17 | PXD044731 | Pride
Proteomics Mass spectrometry Eukaryote genome evolution Saccharomycopsis 
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