Sort   by:  
 Page size 
TranscriptomicsGene and pathways affected by CAG-repeat RNA-based toxicity in Drosophila
Spinocerebellar ataxia type 3 (SCA3) is one of the polyglutamine (polyQ) diseases, which are caused by a CAG repeat expansion within the coding region of the associated genes. The CAG repeat specifies glutamine, and the expanded polyQ domain with mutation confers dominant toxicity on the protein. Tr...
ORGANISM(S): Drosophila melanogaster 
2011-11-22 | E-GEOD-31875 | biostudies-arrayexpress
TranscriptomicsContinuous analysis captures cellular states that reflect dominant effects of the HTT CAG repeat in human lymphoblastoid cell lines.
In Huntington’s disease (HD), expanded HTT CAG repeat length correlates strongly with age at motor onset, indicating that it determines the rate of the disease process leading to diagnostic clinical manifestations. Similarly, in normal individuals, HTT CAG repeat length is correlated with biochemica...
ORGANISM(S): Homo sapiens 
2013-05-03 | E-GEOD-34721 | biostudies-arrayexpress
UnknownAll three MutL complexes are required for repeat expansion in a human stem cell model of CAG-repeat expansion mediated glutaminase deficiency.
Not available
S-EPMC11178883 | biostudies-literature
UnknownDNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases.
Not available
S-EPMC8609077 | biostudies-literature
UnknownAll three MutL complexes are required for repeat expansion in a human stem cell model of CAG-repeat expansion mediated glutaminase deficiency.
Not available
S-EPMC10802475 | biostudies-literature
TranscriptomicsGene and pathways affected by CAG-repeat RNA-based toxicity in Drosophila
Spinocerebellar ataxia type 3 (SCA3) is one of the polyglutamine (polyQ) diseases, which are caused by a CAG repeat expansion within the coding region of the associated genes. The CAG repeat specifies glutamine, and the expanded polyQ domain with mutation confers dominant toxicity on the protein. Tr...
ORGANISM(S): Drosophila melanogaster 
2011-11-22 | GSE31875 | GEO
ProteomicsAntagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability
Ongoing CAG expansions in Spinocerebellar ataxia type 1 (SCA1) and Huntington disease (HD) brains exacerbate disease.  Expansions involve aberrant repair of mutagenic slipped-DNAs, formed from single-stranded DNAs.  Whether singlestranded DNA-binding proteins prevent or facilitate expansions is unkn...
ORGANISM(S): Homo sapiens (Human) 
2023-10-13 | PXD044158 | Pride
Cag repeat expansion diseases  spinocerebellar ataxia type 1 (sca1)  huntington's disease (hd)  somatic cag repeat expansions  rpa (single-strand dna binding protein  alternative-rpa (alt-rpa)  dna repair Slipped-dnas  post-mortem brains Sca1 mice 
UnknownBase excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion.
Not available
S-EPMC3973345 | biostudies-literature
GenomicsCAG repeat-selective compunds reduce abundance of expanded CAG RNAs in patient and murine models of SCAs I
CAG repeat-selective compunds reduce abundance of expanded CAG RNAs in patient and murine models of SCAs I
PRJNA1049476 | ENA
UnknownSequencing analysis of the spinal bulbar muscular atrophy CAG expansion reveals absence of repeat interruptions.
Not available
S-EPMC3898077 | biostudies-literature
Sort   by:  
 Page size