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MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
UnknownTwo new species, one new record, and one new synonym of <i>Aeschynanthus</i> (Gesneriaceae) from China.
Not available
S-EPMC12606072 | biostudies-literature
UnknownCNP signal pathway up-regulated in rectum of depressed rats and the interventional effect of Xiaoyaosan.
Not available
S-EPMC4316094 | biostudies-literature
UnknownGlobal disease burden of stroke attributable to high fasting plasma glucose in 204 countries and territories from 1990 to 2019: An analysis of the Global Burden of Disease Study.
Not available
S-EPMC9426282 | biostudies-literature
MetabolomicsDistinct metabolic profiling is correlated with bisexual flowers formation resulting from exogenous ethephon induction in melon (Cucumis melo L.)

Melon (Cucumis melo L.) is an agronomically important vegetable. Most cultivars of melon are andromonoecious and bisexual flowers only emerged from the leaf axil of lateral branches. However, the regulatory mechanism contributing to the occurrence of bisexual flowers were still obscure. ...

2022-03-10 | MTBLS2993 | MetaboLights
UnknownProximal-dominant knee-ankle coordination compensations in football players with chronic ankle instability under high load.
Not available
S-EPMC12527221 | biostudies-literature
ProteomicsComparative exo-proteomic analysis of Trichoderma antagonists induced by oomycete mycelium highlights diverse antagonism strategies
Plant-beneficial fungi from the genus Trichoderma (Hypocreales, Ascomycota) can control oomyceteous plant-pathogenic Pythium myriotylum (Peronosporales, Oomycota) and thus serve as bioeffectors for the eco-friendly products of crop protection. However, the underlying mechanisms of microbe-microbe in...
ORGANISM(S): Trichoderma asperellum CBS 433.97 Trichoderma virens Gv29-8 Hypocrea jecorina (strain QM6a) (Trichoderma reesei) Trichoderma atroviride IMI 206040 Trichoderma parepimyces Trichoderma guizhouense 
2024-07-19 | PXD051895 | Pride
Trichoderma Exo-proteins Hydrolyase Antagonism 
UnknownCoupled strategy based on regulator manipulation and medium optimization empowers the biosynthetic overproduction of lincomycin.
Not available
S-EPMC10840354 | biostudies-literature
UnknownWTX-L/β-arrestin2/LCN2 axis controls vulnerability to ferroptosis in gastric cancer.
Not available
S-EPMC11919608 | biostudies-literature
MetabolomicsAltered metabolome and microbiome features provide clues in understanding irritable bowel syndrome and depression comorbidity

Irritable bowel syndrome (IBS) is one of the functional gastrointestinal disorders characterized by chronic and/or recurrent symptoms of abdominal pain and irregular defecation. Changed gut microbiota has been proposed to mediate IBS; however, contradictory results exist, and IBS-specific microbi...

2021-12-01 | MTBLS2774 | MetaboLights
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