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ProteomicsProteomic analysis in S100A16-overexpressed human gastric cancer cells lines
Our studies reveal that S100A16 overexpression triggers GC cells proliferation and migration both in vivo and in vitro; by contrast, S100A16 knockdown restricts the speed of GC cells growth and mobility. Proteomic analysis results reveal a large S100A16 interactome, which includes ZO-2 (Zonula Occlu...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD028022 | Pride
Human S100a16 Sgc-7901 cells Gastric cancer 
MetabolomicsMetabolite of esculetin plays an important role in cytotoxic effects induced by chloroquine on porcine immature Sertoli cells

Chloroquine (CQ) is widely used in the therapy against malarial, tumor and recently the COVID-19 pandemic, as a lysosomotropic agent to inhibit the endolysosomal trafficking in the autophagy pathway. We previously reported that CQ (20 µM, 36 h) could reprogram transcriptome and impair multiple si...

2024-07-08 | MTBLS9273 | MetaboLights
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