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UnknownOne- and two-year clinical outcomes of treatment with resorbable magnesium scaffolds for coronary artery disease: the prospective, international, multicentre BIOSOLVE-IV registry.

Background

Bioresorbable scaffolds have been developed to overcome the limitations of drug-eluting stents and to reduce long-term adverse events.

Aims

We aimed to assess the long-term safety and efficacy of a sirolimus-eluting resorbable magnesium scaffold to ensure its safe rollout i...
S-EPMC10266381 | biostudies-literature
UnknownBIOSOLVE-IV-registry: Safety and performance of the Magmaris scaffold: 12-month outcomes of the first cohort of 1,075 patients.

Objectives

We aimed to assess the safety and performance of the Magmaris sirolimus-eluting bioresorbable magnesium scaffold in a large patient population.

Background

Magmaris has shown good outcomes in small-sized controlled trials, but further data are needed to confirm its usability...
S-EPMC8359313 | biostudies-literature
ProteomicsNormoglycemia and physiological cortisone level maintain glucose homeostasis in a pancreas-liver microphysiological system
Current research on metabolic disorders and diabetes relies on animal models because multi-organ diseases cannot be well studied with the standard in vitro assays. Here, we connect models of key metabolic organs, pancreas and liver, on a microfluidic chip to enable diabetes research in a human-based...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD052854 | Pride
Type 2 diabetes mellitus Metabolic disorders Microphysiological system Human pancreatic islets Glucocorticoids Hyperglycemia Transcriptomics Diabetes Proteomics Liver Pancreas 
UnknownGaussian Mixture Models and Model Selection for [18F] Fluorodeoxyglucose Positron Emission Tomography Classification in Alzheimer's Disease.
We present a method to discover discriminative brain metabolism patterns in [18F] fluorodeoxyglucose positron emission tomography (PET) scans, facilitating the clinical diagnosis of Alzheimer's disease. In the work, the term "pattern" stands for a certain brain region that characterizes a target gro...
S-EPMC4412726 | biostudies-literature
UnknownExploring Links Between Psychosis and Frontotemporal Dementia Using Multimodal Machine Learning: Dementia Praecox Revisited.

Importance

The behavioral and cognitive symptoms of severe psychotic disorders overlap with those seen in dementia. However, shared brain alterations remain disputed, and their relevance for patients in at-risk disease stages has not been explored so far.

Objective

To use machine lear...
S-EPMC9350851 | biostudies-literature
UnknownAnalysis of shared heritability in common disorders of the brain.
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and ...
S-EPMC6097237 | biostudies-literature
UnknownEnhanced postoperative surveillance versus standard of care to reduce mortality among adult surgical patients in Africa (ASOS-2): a cluster-randomised controlled trial.

Background

Risk of mortality following surgery in patients across Africa is twice as high as the global average. Most of these deaths occur on hospital wards after the surgery itself. We aimed to assess whether enhanced postoperative surveillance of adult surgical patients at high risk of po...
S-EPMC8440223 | biostudies-literature
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