Hyperglycemia - OmicsDI

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Organisms

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6490 Triple Quadrupole LC/MS (Agilent) (1)
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2010 (25)
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UNIPROT ID/AC

P01308 (2)
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Q96G03 (1)
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CHEBI ID

CHEBI:30769 (5)
CHEBI:44897 (3)
CHEBI:32816 (3)
CHEBI:17659 (3)
CHEBI:16027 (3)
CHEBI:18357 (1)
CHEBI:422 (1)
CHEBI:4170 (1)
CHEBI:30744 (1)
CHEBI:4167 (1)
CHEBI:15713 (1)
CHEBI:16077 (1)
CHEBI:28087 (1)
CHEBI:15377 (1)
CHEBI:24636 (1)
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CHEBI:15346 (1)
CHEBI:29052 (1)
CHEBI:18066 (1)
CHEBI:15996 (1)
CHEBI:17552 (1)
CHEBI:28602 (1)
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CHEBI:16001 (1)
CHEBI:16905 (1)
CHEBI:15422 (1)
CHEBI:16761 (1)
CHEBI:16908 (1)
CHEBI:16526 (1)

Metabolite Name

Glycine (4)
Creatine (4)
L-Lysine (3)
Putrescine (3)
L-Arginine (3)
L-Threonine (3)
Cholesterol (3)
Cytosine (3)
L-Serine (3)
Sucrose (3)
L-Isoleucine (3)
L-Leucine (3)
L-Methionine (3)
L-Tyrosine (3)
L-Cysteinylglycine disulfide (2)
Ribitol (2)
LysoPC(20:4(5Z,8Z,11Z,14Z)) (2)
LysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)) (2)
N-Acetylserine (2)
D-Glucose (2)
Leucine (2)
AMP (2)
2-oxoadipate (2)
Choline (2)
Alanine (2)
3-hydroxybutyrate (2)
Glycerol (2)
Glycine (2)
Uracil (2)
L-glutamine (2)

First Public Date

2025 (87)
2024 (82)
2026 (68)
2014 (60)
2023 (47)
2021 (46)
2022 (37)
2020 (33)
2019 (26)
2017 (22)
2018 (19)
2016 (16)
2015 (14)
2013 (5)

Modelling Approach

Ordinary differential equation model (2)

Study status

Recruiting (2)
Not yet recruiting (1)
Completed (1)

Lab affiliation

Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany (3)
Inserm U1016, Institut Cochin, 24 rue du Faubourg Saint-Jacques, 75014 PARIS, FRANCE. (2)
Toronto General Hospital, University of Toronto, Toronto, Canada (2)
Proteomics and Metabolomics research program, Basic research department, Children’s Cancer Hospital 57357, Cairo, Egypt (1)
Cancer Signalling Research Group, School of Biomedical Science and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, AUSTRALIA. Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, AUSTRALIA. (1)
Thoracic and GI Malignancies Branch, CCR, NCI, NIH, Bethesda, MD (1)
University of Colorado - Anschutz Medical Campus, Department of Biochemistry and Molecular Genetics, Aurora, CO USA (1)
Department of Cell and Regenerative Biology Department of Chemistry Director of Mass Spectrometry Human Proteomics Program University of Wisconsin-Madison (1)
Sun Yat-sen Memorial Hospital,Sun Yat-sen University 107 Yanjiang West Road Guangzhou 510120, P. R. China (1)
Labo Pathophysiology, Department of Biomedical Sciences, University of Antwerp. Belgium (1)
Department of Molecular Physiology and Biophysics, University of Iowa, Iowa city, IA (1)
Centre for Pheromone Technology, Department of Animal Science, Bharathidasan University, Tiruchirappalli - 620024, Tamilnadu, India. (1)
Professor and Deputy Director, Center for Systems Biology and Molecular Medicine Yenepoya Research Centre Yenepoya (Deemed to be University) University Road, Deralakatte Mangalore 575018, India Phone: 0824-2204668 (Ext:2057) Email:csbmm@yenepoya.edu.in (1)
Segal Cancer Proteomics Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Quebec, H3T 1E2, Canada Gerald Bronfman Department of Oncology, McGill University, Montréal, Quebec H4A 3T2, Canada Department of Pathology, McGill University, Montréal,Quebec H4A 3J1, Canada (1)
Dr. Sarah Franklin, Principal Investigator, CVRTI, University of Utah (1)
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital 300384 (1)
Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (1)
Molecular Mechanisms of Disease Research Group, Malopolska Centre of Biotechnology, Jagiellonian University, 30-387 Krakow, Poland (1)
Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany (1)
Departamento de Química Analítica, Química Física e Ingeniería Química, Universidad de Alcalá, Ctra. Madrid-Barcelona, Km. 33.600, 28871 Alcalá de Henares, Madrid, España (1)
Cell Biology and Physiology, Washington University in St. Louis (1)
Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P. R. China (1)
Department of Opthalmology, Boston Children's Hospital, Harvard Medical School (1)
Department of Cell Physiology and Metabolism, Faculty of medicine, University of Geneva (1)
INSERM, U1016, Institut Cochin, F-75014 Paris, France. CNRS, UMR8104, F-75014 Paris, France. Université de Paris, Université Paris Descartes, F-75014 Paris, France. (1)
Laboratory of Neural Development and Regeneration, CIBIO Department - University of Trento Via Sommarive 9, 38123 Trento, ITALY Centre for Medical Sciences - CISMed University of Trento Via S. Maria Maddalena 1, 38122 Trento, Italy (1)
Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA (1)
Joslin Diabetes Center/Harvard Medical School (1)
Indiana University School of Medicine, USA (1)
University of Geneva, Faculty of Medicine, Department of Cell physiology and Metabolism (1)

Keyword

Cgm (1)
Aprepitant (1)
Tropisetron (1)
Dexamethasone (1)

IsPrivate

False (3)

Model Flag

Non Kinetic (1)

Study type

Transcription profiling by array (120)
RNA-seq of coding RNA (16)
Methylation profiling by array (6)
RNA-seq of coding RNA from single cells (3)
Interventional (3)
ChIP-seq (2)
Unknown experiment type (1)
Animal - High-throughput sequencing (1)
ChIP-chip by array (1)
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Observational (1)

Release Date

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1997 (1)

Location

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The accumulation of methylglyoxal and acrolein leads to arginine depletion causing hyperglycemia and renal abnormalities

There is growing evidence to support the idea that the accumulation of reactive carbonyl species plays a significant causal role in the pathogenesis of ageing, cardiovascular diseases, diabetes and its complications. Among reactive carbonyl species, methylglyoxal and acrolein, detoxified by glyox...

2026-06-17 | MTBLS14089 | MetaboLights

Postnatal hyperglycemia alters amino acid profile in retinas

Not available

ORGANISM(S): Mus musculus

ST002497 | MetabolomicsWorkbench

Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells (ChIP-seq)

We report that hyperglycemia-mediated induction of genes and pathways associated to endothelial dysfunction occur through modulation of acetylated H3K9/K14 inversely correlated with methyl-CpG content. Examination of H3K9/K14 histone acetylation and DNA methylation in hyperglycemic conditions.

ORGANISM(S): Homo sapiens

2011-06-01 | E-GEOD-29251 | biostudies-arrayexpress

Chronic high glucose condition reduced expressions of intercellular adhesion molecules and increased intercellular hyperpermeability in periodontal epithelium.

There is a close relationship between hyperglycemia in diabetes and progression of periodontal disease. This study aims to investigate the effect of hyperglycemia on the barrier function of gingival epithelial cells as a cause of hyperglycemia-exacerbated periodontitis in diabetes mellitus. Abnormal...

ORGANISM(S): Mus Musculus (mouse)

2023-07-29 | PXD035613 | JPOST Repository

Gene expression profiles for hyperglycemia induced tumors and mammary glands compared to those in euglycemia

Analysis of hyperglycemia-induced tumor progression at gene expression level. The hypothesis tested in the present study was that hyperglycemia contributes to tumor growth and metastasis. Results provide important information of the response of hyperglycemia, such as specific NRG1 pathways, HER2-3 p...

ORGANISM(S): Mus musculus

2012-08-24 | E-GEOD-40361 | biostudies-arrayexpress

Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells (gene expression)

ORGANISM(S): Homo sapiens

2011-07-19 | E-GEOD-30780 | biostudies-arrayexpress

Thrombospondin-1: A Pro-Atherosclerotic Protein Augmented by Hyperglycemia

Diabetes is associated with a more aggressive form of atherosclerosis. Thrombospondin-1 (TSP-1), an extracellular matrix protein, is an acute phase reactant that induces vascular smooth muscle (VSMC) migration and proliferation in areas of vascular injury, and is also upregulated in VSMCs exposed to...

ORGANISM(S): Homo sapiens

2009-08-11 | E-GEOD-17556 | biostudies-arrayexpress

Combined dietary omega-3 and omega-6 fatty acids protect against hyperglycemia-associated retinopathy in neonatal mice

Introduction: Retinopathy of prematurity (ROP) with early vessel loss (Phase I) followed by uncontrolled vessel growth (Phase II) causes visual impairment in premature infants. Although supplementation with n-3 docosahexaenoic acid (DHA) alone has mixed results to prevent ROP, combined supplementati...

ORGANISM(S): Mus musculus (Mouse)

2025-09-29 | PXD061307 | Pride

Polymorphisms associated with post-COVID-19 hyperglycemia using the Axiom Human Genotyping SARS-CoV-2 Research Array

To investigate the association between polymorphisms in innate immune genes and post-COVID-19 hyperglycemia

ORGANISM(S): Homo sapiens

2025-08-30 | E-MTAB-15470 | biostudies-arrayexpress

Hyperglycemia-independent neonatal streptozotocin-induced retinopathy (NSIR) in rats

PRJNA1136409 | ENA

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