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ProteomicsDevelopment of a SIN1 targeting inhibitor as a novel therapeutic approach for the treatment of malignancies
We have developed a novel mTOR pathway inhibitor via targeting SIN1. We used multiple proteomics analyses to determine mechanism of action of our novel Sin1 inhibitor and compare to other mTOR pathway inhibitors.
ORGANISM(S): Homo sapiens (Human) 
2026-01-26 | PXD040952 | Pride
Cancer Drug development Mtor pathway 
ProteomicsDeep Profiling of Plasma Proteoforms with Engineered Nanoparticles for Top-down Proteomics
Raw data for the manuscript entitled "Deep Profiling of Plasma Proteoforms with Engineered Nanoparticles for Top-down Proteomics"
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-06-19 | MSV000095086 | MassIVE
TranscriptomicsDifferential expression of mouse Grem1+ Vs. Grem1- bone-marrow cells
The gene expression of bone marrow cells of mice enriched for Gremlin1 vs control was measured (n=3). It is not known if endogenous adult mesenchymal stem cells (MSCs) exist.Following culture,perisinusoidal mesenchymal cells can clonally recapitulate the skeletal microenvironment, but this fails to ...
ORGANISM(S): Mus musculus 
2015-02-10 | E-GEOD-57729 | biostudies-arrayexpress
ProteomicsSingle Cell Proteoform Analysis Using scPiMS
We introduce single-cell Proteoform imaging Mass Spectrometry (scPiMS), which realizes the benefit of direct solvent extraction and MS detection of intact proteins from single cells drop casted onto glass slides. Sampling and detection of whole proteoforms by individual ion mass spectrometry enables...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-02-02 | MSV000093994 | MassIVE
MetabolomicsSuccinate accumulation drives ischaemia-reperfusion injury during organ transplantation
During heart transplantation, storage in cold preservation solution is thought to protect the organ by slowing metabolism; by providing osmotic support; and by minimising ischaemia-reperfusion (IR) injury upon transplantation into the recipient. Despite its widespread use, our understanding of the m...
2019-09-20 | MTBLS1085 | MetaboLights
UnknownRisk of COVID-19 after natural infection or vaccination.
Not available
S-EPMC10518569 | biostudies-literature
UnknownEfficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19 : A Randomized Controlled Trial.
Not available
S-EPMC9384272 | biostudies-literature
UnknownA randomized trial of therapies for type 2 diabetes and coronary artery disease.
Not available
S-EPMC2863990 | biostudies-literature
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
UnknownThe Association of Baseline Plasma SARS-CoV-2 Nucleocapsid Antigen Level and Outcomes in Patients Hospitalized With COVID-19.
Not available
S-EPMC9447373 | biostudies-literature
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