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TranscriptomicsDNA methylation profiling of male human pancreatic islets identifies loci for type 2 diabetes
Little is known about the contribution of the epigenome to the pathophysiology of type 2 diabetes (T2D). Here we have used genome-wide DNA methylation profiling to obtain the first comprehensive DNA methylation data set for human T2D pancreatic islets. Therefore, we analyzed the methylation profile ...
ORGANISM(S): Homo sapiens 
2012-04-22 | E-GEOD-21232 | biostudies-arrayexpress
TranscriptomicsEpigenome analysis of genomic DNA isolated from whole blood of non-diabetic control and type-2 diabetic individuals
DNA methylation profiling of whole blood using Illumina's Infinium HumanMethylation27 Beadchip array. The dataset encompasses profiles of 12 non-diabetic control blood donors and 12 type-2 diabetic (T2D) individuals. Bisulfite converted DNA from 24 blood samples were hybridised to the Illumina Infin...
ORGANISM(S): Homo sapiens 
2012-04-22 | E-GEOD-34008 | biostudies-arrayexpress
TranscriptomicsEvaluation of the Infinium Methylation 450K technology
Genome-wide DNA methylation profiling of HCT116 WT, HCT116 DNMT1 and DNMT3B double KO, and breast cancer tumors by next generation Infinium assay Bisulfite converted DNA from 22 samples were hybridized to the Illumina's HumanMethylation450 BeadChip
ORGANISM(S): Homo sapiens 
2011-12-15 | E-GEOD-29290 | biostudies-arrayexpress
TranscriptomicsEpigenetic portraits of human breast cancers (methylation data)
Breast cancer is a molecularly, biologically and clinically heterogeneous group of disorders. Understanding this diversity is essential to improving diagnosis and optimising treatment. Both genetic and acquired epigenetic abnormalities participate in cancer, but information is scant on the involveme...
ORGANISM(S): Homo sapiens 
2011-10-18 | E-GEOD-20712 | biostudies-arrayexpress
TranscriptomicsEpigenetic portraits of human breast cancers (methylation data 2)
Breast cancer is a molecularly, biologically and clinically heterogeneous group of disorders. Understanding this diversity is essential to improving diagnosis and optimising treatment. Both genetic and acquired epigenetic abnormalities participate in cancer, but information is scant on the involveme...
ORGANISM(S): Homo sapiens 
2011-10-18 | E-GEOD-22249 | biostudies-arrayexpress
TranscriptomicsEpigenetic portraits of human breast cancers (HCT116 cell line data)
Breast cancer is a molecularly, biologically and clinically heterogeneous group of disorders. Understanding this diversity is essential to improving diagnosis and optimising treatment. Both genetic and acquired epigenetic abnormalities participate in cancer, but information is scant on the involveme...
ORGANISM(S): Homo sapiens 
2011-10-18 | E-GEOD-20868 | biostudies-arrayexpress
TranscriptomicsEpigenetic portraits of human breast cancers (various cell lines expression data)
Breast cancer is a molecularly, biologically and clinically heterogeneous group of disorders. Understanding this diversity is essential to improving diagnosis and optimising treatment. Both genetic and acquired epigenetic abnormalities participate in cancer, but information is scant on the involveme...
ORGANISM(S): Homo sapiens 
2011-10-18 | E-GEOD-22250 | biostudies-arrayexpress
TranscriptomicsEpigenetic portraits of human breast cancers (various cell lines methylation data)
Breast cancer is a molecularly, biologically and clinically heterogeneous group of disorders. Understanding this diversity is essential to improving diagnosis and optimising treatment. Both genetic and acquired epigenetic abnormalities participate in cancer, but information is scant on the involveme...
ORGANISM(S): Homo sapiens 
2011-10-18 | E-GEOD-22281 | biostudies-arrayexpress
TranscriptomicsEpigenetic portraits of human breast cancers (expression data)
Breast cancer is a molecularly, biologically and clinically heterogeneous group of disorders. Understanding this diversity is essential to improving diagnosis and optimising treatment. Both genetic and acquired epigenetic abnormalities participate in cancer, but information is scant on the involveme...
ORGANISM(S): Homo sapiens 
2011-10-18 | E-GEOD-20711 | biostudies-arrayexpress
GenomicsGenome-wide hydroxymethylcytosine pattern changes in response to oxidative stress
The TET-family enzymes (TETs) convert methylcytosine to hydroxymethylcytosine, a lately discovered epigenetic modification that can modulate transcription. While recent reports suggest that TETs may play a role in response to oxidative stress, this role remains uncertain. Here we show that Tet1 is s...
ORGANISM(S): Homo sapiens 
2016-01-14 | E-GEOD-59718 | biostudies-arrayexpress
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