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ProteomicsIdentifying putative substrates of Calpain-15 in neurodevelopment
Calpain 15 (CAPN15) is an intracellular cysteine protease belonging to the non-classical small optic lobe (SOL) family of calpains, which has an important role in developmental processes. Loss of Capn15 in mice leads to developmental eye anomalies and volumetric changes in the brain. Human individua...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD060034 | Pride
Calpain-15 Capn15 Protease Tails 
UnknownIdentifying putative substrates of Calpain-15 in neurodevelopment.
Not available
S-EPMC12002525 | biostudies-literature
TranscriptomicsIdentifying Putative Targets of Capn15 in Neurodevelopment
Calpain 15 (CAPN15), part of the non-classical SOL family, plays a key role in neurodevelopment. This study used RNA-seq in P2 mice (7 KO and 7 WT) to investigate transcriptomic changes after loss of CAPN15. Differential expression analysis identified Pax2 targets as significantly regulated in CAPN1...
ORGANISM(S): Mus musculus 
2025-04-23 | GSE287980 | GEO
ProteomicsProteomic QSAR analysis of calpain substrate specificity
Calpains are intracellular Ca2+-regulated cysteine proteases that are essential for various cellular functions. Mammalian conventional calpains (calpain-1 and calpain-2) modulate the structure and function of their substrates by limited proteolysis; however, their substrate specificity remains uncle...
ORGANISM(S): Bos taurus (Bovine) Oryctolagus cuniculus algirus Mus musculus (Mouse) Homo sapiens (Human) Gallus gallus (Chicken) Ovis aries Sus scrofa domesticus (domestic pig) Rattus norvegicus (Rat) 
2016-07-19 | PXD002532 | Pride
Calpain Pls Qsar Substrate specificity 
UnknownCalpain-2 as a Treatment Target in Prenatal Stress-induced Epileptic Spasms in Infant Rats.
Not available
S-EPMC6751866 | biostudies-literature
UnknownPerturbation with intrabodies reveals that calpain cleavage is required for degradation of huntingtin exon 1.
Not available
S-EPMC3031625 | biostudies-literature
UnknownIdentification and Functional Validation of a Biomarker for the Diagnosis of Miltefosine Relapse during Visceral Leishmaniasis.
Not available
S-EPMC5929172 | biostudies-literature
UnknownCalpain chronicle--an enzyme family under multidisciplinary characterization.
Not available
S-EPMC3153876 | biostudies-literature
UnknownScreening of calpain-3 autolytic activity in LGMD muscle: a functional map of CAPN3 gene mutations.
Not available
S-EPMC2597906 | biostudies-literature
UnknownRegulation and physiological roles of the calpain system in muscular disorders.
Not available
S-EPMC3444232 | biostudies-literature
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