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GenomicsIdentifying Putative Targets of Capn15 in Neurodevelopment
Identifying Putative Targets of Capn15 in Neurodevelopment
PRJNA1215400 | ENA
ProteomicsIdentifying putative substrates of Calpain-15 in neurodevelopment
Calpain 15 (CAPN15) is an intracellular cysteine protease belonging to the non-classical small optic lobe (SOL) family of calpains, which has an important role in developmental processes. Loss of Capn15 in mice leads to developmental eye anomalies and volumetric changes in the brain. Human individua...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD060034 | Pride
Calpain-15 Capn15 Protease Tails 
TranscriptomicsIdentifying Putative Targets of Capn15 in Neurodevelopment
Calpain 15 (CAPN15), part of the non-classical SOL family, plays a key role in neurodevelopment. This study used RNA-seq in P2 mice (7 KO and 7 WT) to investigate transcriptomic changes after loss of CAPN15. Differential expression analysis identified Pax2 targets as significantly regulated in CAPN1...
ORGANISM(S): Mus musculus 
2025-04-23 | GSE287980 | GEO
UnknownCAPN15 is a non-proteasomal, ubiquitin-directed calpain protease that regulates cell adhesion by cleaving E-cadherin.
Not available
S-EPMC12805371 | biostudies-literature
UnknownNovel association of Dandy-Walker malformation with CAPN15 variants expands the phenotype of oculogastrointestinal neurodevelopmental syndrome.
Not available
S-EPMC11141336 | biostudies-literature
UnknownBiallelic variants in the small optic lobe calpain CAPN15 are associated with congenital eye anomalies, deafness and other neurodevelopmental deficits.
Not available
S-EPMC7645705 | biostudies-literature
TranscriptomicsGene expression in HeLa cells expressing GFP-IRF3 (non-targeting control and clonal knockouts of DDX58, MAVS, ATP13A1, CAPN15, TADA2B, MED16, and MED24) following Sendai virus (SeV) infection or hpRNA transfection
IRF3 translocates from the cytoplasm to the nucleus upon recognition of a cytoplasmic RNA stimulus by RIG-I or MDA5. Using an optical pooled CRISPR knockout screen in HeLa-Cas9 cells, we identified ATP13A1, CAPN15, TADA2B, MED16, and MED24 as novel genes affecting the translocation of IRF3 upon Send...
ORGANISM(S): Homo sapiens 
2023-03-05 | GSE179288 | GEO
GenomicsGene expression in HeLa cells expressing GFP-IRF3 (non-targeting control and clonal knockouts of DDX58, MAVS, ATP13A1, CAPN15, TADA2B, MED16, and MED24) following Sendai virus (SeV) infection or hpRNA transfection
Gene expression in HeLa cells expressing GFP-IRF3 (non-targeting control and clonal knockouts of DDX58, MAVS, ATP13A1, CAPN15, TADA2B, MED16, and MED24) following Sendai virus (SeV) infection or hpRNA transfection
PRJNA743068 | ENA
ProteomicsHuman CAPN15 interacting prtoeins
This mass spectrometry data set provides a comprehensive list of CAPN15 interacting proteins in HCT116 cells.
ORGANISM(S): Homo Sapiens (human) 
2025-11-25 | PXD059028 | JPOST Repository
UnknownIdentifying putative substrates of Calpain-15 in neurodevelopment.
Not available
S-EPMC12002525 | biostudies-literature
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