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TranscriptomicsTranscription profiling of human LNCaP cell lines transfected with AIbZIP
Androgen-induced bZIP (AIbZIP) is a basic leucine zipper (bZIP); transcription factor that is encoded by the CREB3L4 (cAMP responsive element; binding protein 3-like 4) gene. In humans, AIbZIP mRNA is most abundant in; the prostate but it is also present, albeit at much lower levels, in the; pancrea...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7223 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of uteri from gonadectomized C57BL/6 mice injected with 17-Estradiol (E2) to identify genes modulated by a physiological dose of E2 in uterus.
17ß-Estradiol (E2) is well known to be associated with uterine cancer, endometriosis, and leiomyomas. Although insulin-like growth factor I (IGF-I) has been identified as a mediator of the uterotrophic effect of E2 in several studies, this mechanism is still not well understood. In the present stud...
ORGANISM(S): Mus musculus 
2007-11-14 | E-GEOD-6219 | biostudies-arrayexpress
TranscriptomicsSpecific transcriptional response of four blockers of estrogen receptors on estradiol-modulated genes in the mouse mammary gland
The efficacy and exceptionally good tolerance of estrogen blockade in the treatment of breast cancer is well recognized but novel agents are required, especially to take advantage of the multiple consecutive responses obtained in breast cancer progressing following previous hormone therapy, thus del...
ORGANISM(S): Mus musculus 
2012-12-05 | E-GEOD-35206 | biostudies-arrayexpress
TranscriptomicsTimecourse expression data from sciatic nerve distal stump of C57BL/6 and C57BL/6 OlaHsd-Wlds mice.
Wallerian degeneration (WD) involves the fragmentation of axonal segments disconnected from their cell bodies, segmentation of the myelin sheath, and removal of debris by Schwann cells and immune cells. The removal and downregulation of myelin-associated inhibitors of axonal regeneration and synthes...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-22291 | biostudies-arrayexpress
TranscriptomicsGenomic analyses of breast cancer cells: 17β-hydroxysteroid dehydrogenase type 1 induces transcriptional changes in estradiol-dependent and independent manners
17β-HSD1 expression modulates T47D transcript profile in in steroid-deprived medium. The enzyme specifically regulates apoptosis and cancer-related genes in T47D cells cultured in steroid-deprived medium. Genes that primarily involved in Cell cycle progression, such as the Cyclin A2 gene, CCNA2, a...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-77345 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human epididymis after vasectomy
Worldwide, almost 100 millions men rely on vasectomy for male contraceptive purposes. Due to changes in their personal life, an increasing number of these men request surgical vasectomy reversal. Unfortunately, a significant proportion of these men remain infertile, despite the reestablishment of pa...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-9731 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse uteri after ovariectomy and DHT treatment.
Morphogenesis of epithelial tissues relies on the precise developmental control of cell polarity and architecture. In the early Drosophila embryo, the primary epithelium forms during cellularisation, following a tightly controlled genetic programme where specific sets of genes are up-regulated. Some...
ORGANISM(S): Mus musculus 
2008-10-18 | E-GEOD-6237 | biostudies-arrayexpress
TranscriptomicsEpididymosomes convey different repertoires of miRNAs throughout the epididymis
Epididymosomes are small membrane vesicles (50-500nm) secreted by epididymal epithelial cells and involved in post-testicular sperm maturation. While their role in protein transfer to the sperm membrane is well acknowledged, we unveil here their capacity to vehicle microRNAs (miRNAs), which are pote...
ORGANISM(S): Bos taurus 
2013-07-01 | E-GEOD-44365 | biostudies-arrayexpress
TranscriptomicsExpression data from Panc1 pancreatic epithelial cells
Krüppel-like factors (KLFs) are a group of master regulators of gene expression conserved from flies to human. However, scant information is available on either the mechanisms or functional impact of the coupling of KLF proteins to chromatin remodeling machines, a deterministic step in transcripti...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-56778 | biostudies-arrayexpress
TranscriptomicsExpression data from advanced stage of murine pancreatic ductal adenocarcinoma (PDAC) and control pancreas
We used microarrays to detail the global gene expression signature of PDAC and to identify distinct up- and down-regulated transcripts in these tumors compared to control pancreas. We also established from this dataset the metabolic signature of PDAC in order to define new metabolic therapeutic targ...
ORGANISM(S): Mus musculus 
2014-09-16 | E-GEOD-61412 | biostudies-arrayexpress
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