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ProteomicsTIMP1 mediates astrocyte-dependent local immunosuppression in brain metastasis acting on infiltrating CD8+ T cells.
Immunotherapies against brain metastases have shown clinical benefits mainly when applied to locally asymptomatic patients. It is currently unclear why responses to this therapy drop in symptomatic brain metastases, since the use of corticoids is not consistently involved. We report here that a subp...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-27 | PXD040436 | Pride
Microenvironment Brain metastasis Immunotherapy 
MetabolomicsDissection of two routes to naïve pluripotency using different kinase inhibitors
Embryonic stem cells (ESCs) can be maintained in the naïve state through inhibition of Mek1/2 and Gsk3 (2i). A relevant effect of 2i is the inhibition of Cdk8/19, which are negative regulators of the Mediator complex, responsible for the activity of enhancers. Inhibition of Cdk8/19 (Cdk8/19i) stimul...
2021-02-10 | MTBLS301 | MetaboLights
UnknownValidation of the knowledge evaluation questionnaire of the cardiopulmonary resuscitation training program in high school students.
Not available
S-EPMC10589594 | biostudies-literature
TranscriptomicsOverexpression of non-degradable SAS-6 KEN box mutant in RPE-1 cells
Stable clones of RPE-1 cells expressing tetracycline-inducible wild type SAS-6 or SAS-6ND were obtained via lentiviral gene transduction with the pLVX tet-on Advanced inducible gene expression system (Clontech). Stable expressors were derived by selection with 5 μg/mL puromycin (Sigma-Aldrich, UK). ...
ORGANISM(S): Homo sapiens 
2025-01-27 | E-MTAB-13783 | biostudies-arrayexpress
UnknownTHZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors.
Not available
S-EPMC5290269 | biostudies-literature
UnknownCombinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas.
Not available
S-EPMC4760090 | biostudies-literature
UnknownAllo-HCT refined ELN 2022 risk classification: validation of the Adverse-Plus risk group in AML patients undergoing allogeneic hematopoietic cell transplantation within the Spanish Group for Hematopoietic Cell Transplantation (GETH-TC).
Not available
S-EPMC11928450 | biostudies-literature
UnknownSafety of Post-Transplant Cyclophosphamide-Based Prophylaxis in AML Patients with Pre-Existing Cardiac Morbidity Undergoing Allogeneic Hematopoietic Cell Transplantation.
Not available
S-EPMC12523613 | biostudies-literature
UnknownGECOP-MMC: phase IV randomized clinical trial to evaluate the efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC) with mytomicin-C after complete surgical cytoreduction in patients with colon cancer peritoneal metastases.
Not available
S-EPMC9097342 | biostudies-literature
UnknownSociodemographic and clinical factors associated with poor COVID-19 outcomes in patients with rheumatic diseases: data from the SAR-COVID Registry.
Not available
S-EPMC9535223 | biostudies-literature
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