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UnknownRandom mutagenesis reveals residues of JAK2 critical in evading inhibition by a tyrosine kinase inhibitor.
Not available
S-EPMC3420867 | biostudies-literature
TranscriptomicsThe role of carbon starvation in the induction of enzymes that degrade plant-derived carbohydrates in Aspergillus niger
Fungi are an important source of enzymes for saccharification of plant polysaccharides and production of biofuels. Understanding of the regulation and induction of expression of genes encoding these enzymes is still incomplete. To explore the induction mechanism, we analysed the response of the indu...
ORGANISM(S): Aspergillus niger 
2014-08-22 | E-GEOD-57315 | biostudies-arrayexpress
UnknownThe RoboCOS Study: Development of an international core outcome set for the comprehensive evaluation of patient, surgeon, organisational and population level impacts of robotic assisted surgery.
Not available
S-EPMC10062593 | biostudies-literature
TranscriptomicsGenome-wide Transcriptional Responses of the Filamentous Fungus Aspergillus niger to Lignocellulose (Wheat straw) using RNA-sequencing
We have studied the physiological response of the fungus Aspergillus niger when exposed to wheat straw as a model lignocellulosic substrate. Using RNA-sequencing we showed that, 24 hours after exposure to straw, gene expression of known plant cell wall degrading enzymes represents a huge investment ...
ORGANISM(S): Aspergillus niger 
2012-08-27 | E-GEOD-33852 | biostudies-arrayexpress
UnknownRisk Algorithm Using Serial Biomarker Measurements Doubles the Number of Screen-Detected Cancers Compared With a Single-Threshold Rule in the United Kingdom Collaborative Trial of Ovarian Cancer Screening.
Not available
S-EPMC4463475 | biostudies-literature
ProteomicsLate-life restoration of mitochondrial function reverses cardiac dysfunction in old mice
Redox proteomic data from the heart of young mice, old mice, or mice treated with SS31. Quantification of protein-S-glutathionylation was performed using an established redox proteomics workflow. LC-MS/MS raw data were searched with MS-GF+ against the mouse protein sequence database from the Uniprot...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-04-23 | MSV000085329 | MassIVE
ProteomicsSIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion
Sirtuins are NAD+-dependent protein deacylases that regulate several aspects of metabolism and aging. In contrast to the other mammalian sirtuins, the primary enzymatic activity of mitochondrial sirtuin 4 (SIRT4) and its overall role in metabolic control has remained enigmatic. Using a combination o...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-05 | PXD005896 | Pride
Protein acylation Insulin secretion Leucine metabolism Sirt4 
ProteomicsBeta-cell Galphas signaling is critical for physiological and pharmacological enhancement of insulin secretion
Islet lysates were adjusted to 5 percent SDS in TEAB, pH 8.5, reduced and alkylated and digested with modified trypsin (Worthington) using an S-trap mini device (Protifi). Peptides were labeled with TMT16 reagents (lot ZH350094). Phosphopeptide enrichment used GL Sciences p10 TiO tips. LC-MS/MS used...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2025-05-13 | MSV000097882 | MassIVE
TranscriptomicsInduction of hepatocellular carcinoma through activation of stromal cells in Pdgf-c transgenic mice
Liver cirrhosis is a strong risk factor for the development of hepatocellular carcinoma (HCC), yet the mechanisms by which cirrhosis predisposes patients to tumorigenesis are not well understood. Transgenic mice expressing platelet-derived growth factor C (Pdgf-c) under the control of the albumin pr...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-38199 | biostudies-arrayexpress
ProteomicsNanodroplet processing platform for deep, quantitative proteome profiling of 10-100 mammalian cells
Proteomic data from 10-100 cultured cells and single human islet cross sections (Healthy control)
ORGANISM(S): Homo sapiens (Human) 
2018-01-24 | PXD006847 | Pride
Ultrasensitive Proteomics Nanopots 
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