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TranscriptomicsSIRT4 KO livers microarray
Sirtuins are a family of protein deacetylases, deacylases, and ADP-ribosyltransferases that regulate life span, control the onset of numerous age-associated diseases, and mediate metabolic homeostasis. We have uncovered a novel role for the mitochondrial sirtuin SIRT4 in the regulation of hepatic ...
ORGANISM(S): Mus musculus 
2014-03-28 | E-GEOD-56321 | biostudies-arrayexpress
ProteomicsSIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion
Sirtuins are NAD+-dependent protein deacylases that regulate several aspects of metabolism and aging. In contrast to the other mammalian sirtuins, the primary enzymatic activity of mitochondrial sirtuin 4 (SIRT4) and its overall role in metabolic control has remained enigmatic. Using a combination o...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-05 | PXD005896 | Pride
Protein acylation Insulin secretion Leucine metabolism Sirt4 
TranscriptomicsSIRT4 KO livers microarray
Sirtuins are a family of protein deacetylases, deacylases, and ADP-ribosyltransferases that regulate life span, control the onset of numerous age-associated diseases, and mediate metabolic homeostasis. We have uncovered a novel role for the mitochondrial sirtuin SIRT4 in the regulation of hepatic li...
ORGANISM(S): Mus musculus 
2014-03-28 | GSE56321 | GEO
ProteomicsAmino Acids Downregulate SIRT4 to Detoxify Ammonia through the Urea Cycle
Ammonia production via glutamate dehydrogenase is inhibited by SIRT4, a sirtuin that displays both amidase and non-amidase activities. The processes underlying the regulation of ammonia removal by amino acids remain unclear. Here, we report that SIRT4 acts as a decarbamylase that responds to amino a...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-29 | PXD037101 | Pride
Carbamylation Liver Mice 
GenomicsRNA-Seq of pancreatic cancer cell line CAPAN-2 with or without SIRT4 overexpression
RNA-Seq of pancreatic cancer cell line CAPAN-2 with or without SIRT4 overexpression
PRJNA828435 | ENA
ProteomicsAP-MS analysis of sirtuin-4 interactions in human fibroblasts
Sirtuins (SIRTs) form a critical family of nicotinamide adenine dinucleotide (NAD)-dependent enzymes that govern genome regulation, metabolism, and aging. Despite conserved deacetylase domains, SIRTs4-7 have little to no deacetylase activity, and a robust catalytic activity for mitochondrial SIRT4 h...
ORGANISM(S): Homo sapiens (Human) 
2015-01-05 | PXD001447 | Pride
Protein interactions Sirt4 Pdh Sirtuin 
TranscriptomicsRNA-Seq of pancreatic cancer cell line CAPAN-2 with or without SIRT4 overexpression
We profile gene expression with or without SIRT4 overexpression in pancreatic cancer cell line CAPAN-2 to find the different genes and pathways regulated by SIRT4.
ORGANISM(S): Homo sapiens 
2022-05-31 | GSE201110 | GEO
GenomicsMus musculus
SIRT4 KO livers microarray
PRJNA242909 | ENA
GenomicsSIRT4 controls acetyl-CoA synthesis to promote stemness and invasiveness of hepatocellular carcinoma through deacetylating MCCC2
SIRT4 controls acetyl-CoA synthesis to promote stemness and invasiveness of hepatocellular carcinoma through deacetylating MCCC2
PRJNA1175040 | ENA
TranscriptomicsDownregulation of miR-15b is associated with increased SIRT4 expression in premature senescence and photoaging of the skin
Sirtuins are deacetylases or ADP-ribosyltransferases which are implicated in multiple pathways involved in metabolism and life-span regulation. Here, we link the mitochondrial sirtuin SIRT4, which overexpression negatively impacts on mitochondrial oxidative capacity, with premature senescence and sk...
ORGANISM(S): Homo sapiens 
2016-06-08 | GSE45729 | GEO
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