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ProteomicsIdentification of PDH XL peptides in Bik1 at different conditions
Identification of PDH crosslinks in Bik1 at different conditions (phase separation and soluble)
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-01-06 | PXD050930 | Pride
Bik1 Pdh Dda 
TranscriptomicsEngineering acetyl-CoA supply: Functional expression of a bacterial pyruvate-dehydrogenase complex in the cytosol of Saccharomyces cerevisiae
The energetic (ATP) cost of biochemical pathways critically determines the maximum yield of metabolites of vital or commercial relevance. Cytosolic acetyl-CoA is a key precursor for biosynthesis in eukaryotes and for many industrially relevant product pathways that have been introduced into Saccharo...
ORGANISM(S): Saccharomyces cerevisiae 
2014-11-04 | E-GEOD-59814 | biostudies-arrayexpress
MetabolomicsSelective galactose culture condition reveals distinct metabolic signatures in pyruvate dehydrogenase and complex I deficient human skin fibroblasts

INTRODUCTION: A decline in mitochondrial function represents a key factor of a large number of inborn errors of metabolism, which lead to an extremely heterogeneous group of disorders.

OBJECTIVES: To gain insight into the biochemical consequences of mitocho...

2021-10-06 | MTBLS761 | MetaboLights
TranscriptomicsTargeting Unique Metabolic Properties of Breast Tumor Initiating Cells
Bulk cancer cell populations are known to display distinct metabolic properties compared to their normal counterparts. However, relatively little is known about heterogeneity of metabolic properties within tumors. In this study we show that, analogous to some normal stem cells, breast tumor initiati...
ORGANISM(S): Mus musculus 
2014-07-31 | E-GEOD-41286 | biostudies-arrayexpress
GenomicsHomo sapiens
PDH gene regulation
PRJDB8731 | ENA
OtherSirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity.
Data from ProteomeXchange, PXD ID: PXD001447. Experiment: SIRT4_MITO_MOCK1, file: SIRT4_MITO_MOCK1_05.mzml. Published as part of Cell. 2014 Dec 18;159(7):1615-25 . From the Abstract: {{i}} ... Here, we establish SIRT4 as a cellular lipoamidase that regulates the pyruvate dehydrogenase complex (PDH)...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320006423 | GPMDB
Resource Reanalysis 
UnknownRheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation.
Not available
S-EPMC9096910 | biostudies-literature
UnknownMetal-Doped PdH(111) Catalysts for CO2 Reduction.
Not available
S-EPMC9320891 | biostudies-literature
UnknownHarvesting PdH Employing Pd Nano Icosahedrons via High Pressure.
Not available
S-EPMC9896048 | biostudies-literature
ProteomicsTissue Transglutaminase 2 has higher affinity for relaxed than for stretched fibronectin fibers
Chemical cross-linking coupled to mass spectrometry was used to study the interaction between fibronectin (Fn; full-length or gelatin-binding domain fragment = Fn 45) with tissue transglutaminase 2 in oxidized and non-oxidized form. The complexes were cross-linked with disuccinimidyl suberate (DSS) ...
ORGANISM(S): Homo sapiens (Human) 
2023-12-20 | PXD043976 | Pride
Chemical cross-linking  dss  pdh  dmtmm  structural proteomics  fibronectin Tissue transglutaminase 2 
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