Sort   by:  
 Page size 
TranscriptomicsInhibitors that block initiation of wall teichoic acid biosynthesis sensitize methicillin-resistant Staphylococcus aureus to beta-lactams
Methicillin resistance in Staphylococcus aureus depends on the production of mecA, which encodes penicillin-binding protein 2A (PBP2A), an acquired peptidoglycan transpeptidase with reduced susceptibility to beta-lactam antibiotics. Here, we show that preventing the expression of wall teichoic acids...
ORGANISM(S): Staphylococcus aureus 
2010-10-19 | E-GEOD-24439 | biostudies-arrayexpress
TranscriptomicsAn antibiotic that inhibits a late step in wall teichoic acid biosynthesis induces the cell wall stress stimulon in Staphylococcus aureus
Wall teichoic acids (WTAs) are phosphate-rich, sugar-based polymers attached to the cell walls of most Gram-positive bacteria. In Staphylococcus aureus, these anionic polymers regulate cell division, protect cells from osmotic stress, mediate host colonization, and mask enzymatically susceptible pep...
ORGANISM(S): Staphylococcus aureus 
2012-01-12 | E-GEOD-34441 | biostudies-arrayexpress
GenomicsInternational Genetics of Parkinson Disease Progression (IGPP) Consortium GWAS Summary Results
To characterize how genetic variation influences the progression of Parkinson’s disease to dementia, which is a major determinant for quality of life, we performed a longitudinal genome-wide survival study (GWSS). Risk profile analysis was performed with a novel polygenic hazard score in longit...
EGAS00001005110 | EGA
Genomics8f81ce09-cd65-468c-a27a-d4f4863b24c4 - samples
The data are the aggregate results from an IGPP Consortium genome-wide survival study, showing overall risk for Parkinson disease progression associated with each variant in a longitudinal cohort study. 11.2 million deeply imputed variants in 3,821 PD patients who were prospectively tracked with 36,...
EGAD00001007060 | EGA
GenomicsInternational Genetics of Parkinson Disease Progression (IGPP) Consortium GWSS Summary Results Data Access Committee
Data Access Committee EGAC00001002012
EGAC00001002012 | EGA
GenomicsQCMG_20140410_OESO - samples
Description not provided
EGAD00001000845 | EGA
GenomicsGenomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis.
Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries. A better understanding of EAC underpins efforts to improve early detection and treatment outcomes. While large EAC exome sequencing efforts to date have found recurrent loss-of-function mutations, oncogenic drivin...
EGAS00001000750 | EGA
GenomicsWhole Genome Sequencing of Esophageal Adenocarcinomas DAC
Data Access Committee EGAC00001000192
EGAC00001000192 | EGA
UnknownChronic kidney disease, cerebral blood flow, and white matter volume in hypertensive adults.
Not available
S-EPMC4818564 | biostudies-literature
UnknownFine-mapping of 150 breast cancer risk regions identifies 191 likely target genes.
Not available
S-EPMC6974400 | biostudies-literature
Sort   by:  
 Page size