Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of Zea mays embryos under camptothecin (CPT) treatment.
Camptothecin (CPT) is a plant alkaloid that specifically binds topoisomerase I (Topo I) inhibiting its activity and inducing double stranded breaks in the DNA, activating the genotoxic cell responses, and ultimately, it might trigger programmed cell death (PCD). We used microarrays to detail the cha...
ORGANISM(S): Zea mays 
2010-11-01 | E-MEXP-2702 | biostudies-arrayexpress
no omics definedTranscription profiling of camptothecin treatment time series performed on human U87 glioma cells
Time-series analysis of camptothecin effects on U87 glioma cells
ORGANISM(S): Homo sapiens 
2006-09-30 | E-MEXP-741 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Hela cells treated with the topoisomerase poison camptothecin
Pharmacogenomic identification of targets for adjuvant therapy with the topoisomerase poison camptothecin. The response of tumor cells to the unusual form of DNA damage caused by topoisomerase poisons such as camptothecin (CPT) is poorly understood, and knowledge regarding which drugs can be effecti...
ORGANISM(S): Homo sapiens 
2007-07-29 | E-GEOD-1417 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling in camptothecin-treated or untreated hepatoma-derived exosomes
Totally 1,308 miRNAs were examined. Three miRNAs (hsa-miR-1976, 4728-3p, and 877-3p) were upregulated with fold change excess 0.8 and six miRNAs (hsa-miR-4497, -204-3p, -6126, -5787, -1273e, and -1908-3p) were downregulated in the exosome released from camptothecin-treated hepatoma. Comparing betwee...
ORGANISM(S): Homo sapiens 
2015-11-10 | E-GEOD-74829 | biostudies-arrayexpress
TranscriptomicsCamptothecin-miRNA
DNA Topoisomerase I inhibition by Camptothecin (CPT) derivatives can impair the hypoxia-induced cell transcriptional response. In the present work, we determined molecular aspects of the mechanism of CPT effects on HIF-1alpha activity in human cancer cells. In particular, we provide evidence that lo...
ORGANISM(S): Homo sapiens 
2013-12-02 | E-MTAB-2022 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of camptothecin treatment time series performed on human DBTRG-05MG glioma cells
Time-series analysis of camptothecin effects on DBTRG-05MG glioma cell line
ORGANISM(S): Homo sapiens 
2006-09-30 | E-MEXP-751 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Transcriptional Effects of the Anti-Cancer Agent Camptothecin
The anti-cancer drug camptothecin inhibits replication and transcription by trapping DNA topoisomerase I (Top1) covalently to DNA in a M-bM-^@M-^\cleavable complexM-bM-^@M-^]. To examine the effects of camptothecin on RNA synthesis genome-wide we used Bru-Seq and show that camptothecin treatment aff...
ORGANISM(S): Homo sapiens 
2013-10-29 | E-GEOD-48678 | biostudies-arrayexpress
TranscriptomicsSnd1-Mtdh interaction regulates cell survival under camptothecin-induced replication stress
PyMT tumor cells with indicated status of Mtdh and Snd1 were treated with camptothecin (CPT) and the transcirptome profiles were determined and compared two sets of experiments: (1) vector control vs Snd1-KD under CPT treament (2) PyMT/Mtdh-KO cells reconstituted with either WT or Snd1-binding defic...
ORGANISM(S): Mus musculus 
2014-08-12 | E-GEOD-55522 | biostudies-arrayexpress
ProteomicsIdentification of post translational modifications of human Topoiosmerase 1 in the presence of camptothecin and CHK1 inhibitor SCH900776.
Topisomerase 1 (TOP1), an essential enzyme in humans, plays a critical role in relaxation of DNA supercoils during replication and transcription. The TOP1 reaction cycle involves an obligate TOP1-DNA covalent complex intermediate (TOP1cc), which is stabilized by TOP1 poisons like camptothecin. While...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD055870 | Pride
Topoisomerase 1 Mk-8776 Chk1 Sch900776 Camptothecin 
TranscriptomicsTranscriptome analysis (Agilent microarrays) of WT, cbf11 and cbf12 Schizosaccharomyces pombe strains treated with camptothecin
The aim was to determine expression levels in untreated cells and cells treated with 20 micromolar camptothecin (CPT) for 2 hours. And the to compare the cbf11 and cbf12 deletion mutants with WT. Cells were grown to exponential phase in YES at 32°C, aliquots of cultures were collected (sample \\"con...
ORGANISM(S): Schizosaccharomyces pombe 
2024-04-05 | E-MTAB-13621 | biostudies-arrayexpress
Sort   by:  
 Page size