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ProteomicsProteomics analysis of FUS mutant human motoneurons reveals altered regulation of cytoskeleton and other ALS-linked proteins via 3’UTR binding
Increasing evidence suggests that in Amyotrophic Lateral Sclerosis (ALS) mutated RNA binding proteins acquire aberrant functions, leading to altered RNA metabolism with significant impact on encoded protein levels. Here, by taking advantage of a human induced Pluripotent Stem Cell (hiPSC)-based mode...
ORGANISM(S): Homo sapiens (Human) 
2020-10-27 | PXD019596 | Pride
Motoneurons Fus protein Vcp  asap1  3’utr  
MetabolomicsMetabolic profiling of Candida clinical isolates of different species and infection sources

Candida species are the most common cause of opportunistic fungal infections. Rapid identification and novel approaches for the characterization of these fungi are of great interest to improve the diagnosis and the knowledge about their pathogenic properties. This study aimed to characte...

2024-07-09 | MTBLS1978 | MetaboLights
UnknownPatient-Reported Outcomes 1 Year After Immediate Breast Reconstruction: Results of the Mastectomy Reconstruction Outcomes Consortium Study.
Not available
S-EPMC5536162 | biostudies-literature
TranscriptomicsTranscription profiling validation of an custom mouse oligo array using liver samples following treatment with the hepatotoxin phenobarbital and variable hybridization protocols
The use of custom-made focused microarrays has become a popular alternative, allowing the study of genes relevant to a specific hypothesis. To address the limitations of commercial arrays in toxicogenomics investigations, we have developed a custom mouse oligonucleotide microarray, the HC ToxArrayTM...
ORGANISM(S): Mus musculus 
2006-10-30 | E-MEXP-525 | biostudies-arrayexpress
UnknownQuality of life in MAP.3 (Mammary Prevention 3): a randomized, placebo-controlled trial evaluating exemestane for prevention of breast cancer.
Not available
S-EPMC4879707 | biostudies-literature
MetabolomicsComparative characterization of the infant gut microbiome and their maternal lineage by a multi-omics approach

The human gut microbiome establishes and matures during infancy, and dysregulation at this stage may lead to pathologies later in life. We conducted a multi-omics study comprising three generations of family members to investigate the early development of the gut microbiota. Fecal samples from 20...

2024-03-07 | MTBLS7670 | MetaboLights
TranscriptomicsSingle nucleus RNA sequencing of human iPSC-derived forebrain organoids to assay cell type composition
Human iPSC line D1 was differentiated into spheroids. After 21 weeks in culture, single nucei were extracted and assayed using single nucleus RNA sequencing to characterize the spheroids' cell type composition.
ORGANISM(S): Homo sapiens 
2021-12-01 | E-MTAB-10605 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing analysis of gilt blood gene expression during Porcine Reproductive and Respiratory Syndrom Virus infection
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnant females causes fetal death and increased piglet mortality, but there is substantial variation in the extent of reproductive pathology between individual dams. This study used RNA-sequencing to characterize the whole bl...
ORGANISM(S): Sus scrofa 
2016-05-17 | E-GEOD-75304 | biostudies-arrayexpress
UnknownA homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease.
Not available
S-EPMC10519206 | biostudies-literature
UnknownHigh-flow nasal oxygen in patients with COVID-19-associated acute respiratory failure.
Not available
S-EPMC7876530 | biostudies-literature
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