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ProteomicsMulit-omics analysis of keratinocytes reveals dermokine as regulator keratinocyte differentiation and adhesion - p120 perturbed proteome
Impaired adhesion and differentiation of keratinocytes is a hallmark of several skin diseases, but only some of the factors that regulate these processes have been identified. Here, we studied the role of isoform-rich dermokine – a wound- and tumor-regulated protein – in keratinocytes using a combin...
ORGANISM(S): Homo sapiens (Human) 
2026-04-09 | PXD074943 | Pride
ProteomicsMulit-omics analysis of keratinocytes reveals dermokine as regulator keratinocyte differentiation and adhesion - 3D Proteome
Impaired adhesion and differentiation of keratinocytes is a hallmark of several skin diseases, but only some of the factors that regulate these processes have been identified. Here, we studied the role of isoform-rich dermokine – a wound- and tumor-regulated protein – in keratinocytes using a combin...
ORGANISM(S): Homo sapiens (Human) 
2026-04-09 | PXD055812 | Pride
ProteomicsMulit-omics analysis of keratinocytes reveals dermokine as regulator keratinocyte differentiation and adhesion - phosphoproteome and proteome
Impaired adhesion and differentiation of keratinocytes is a hallmark of several skin diseases, but only some of the factors that regulate these processes have been identified. Here, we studied the role of isoform-rich dermokine – a wound- and tumor-regulated protein – in keratinocytes using a combin...
ORGANISM(S): Homo sapiens (Human) 
2026-04-09 | PXD050151 | Pride
ProteomicsMatrix metalloproteinase landscape in the imiquimod-induced skin inflammation mouse model
Inflammation and autoimmunity are known as central processes in many skin diseases, including psoriasis. It is therefore important to develop pre-clinical models that describe disease-related aspects to enable testing of pharmaceutical drug candidates and formulations to essentially develop safe and...
ORGANISM(S): Mus Musculus 
2025-10-31 | PXD046049 | panorama
ProteomicsPathological meprin a activity associated with degradation of dermokine drives a psoriasis-like skin phenotype in a novel genetic mouse model
Keratinocyte proliferation and differentiation is regulated via proteolytic networks. Dysregulation of proteases within these systems can cause hyperproliferative and inflammatory skin disorders. In healthy skin the metalloprotease meprin α is localized in the stratum basale, yet in wound healing ti...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-03 | PXD063928 | Pride
Degradomics Dia Mouse Psoriasis Tails Dermokine 
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