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ProteomicsMulit-omics analysis of keratinocytes reveals dermokine as regulator keratinocyte differentiation and adhesion - 3D Proteome
Impaired adhesion and differentiation of keratinocytes is a hallmark of several skin diseases, but only some of the factors that regulate these processes have been identified. Here, we studied the role of isoform-rich dermokine – a wound- and tumor-regulated protein – in keratinocytes using a combin...
ORGANISM(S): Homo sapiens (Human) 
2026-04-09 | PXD055812 | Pride
ProteomicsMulit-omics analysis of keratinocytes reveals dermokine as regulator keratinocyte differentiation and adhesion - p120 perturbed proteome
Impaired adhesion and differentiation of keratinocytes is a hallmark of several skin diseases, but only some of the factors that regulate these processes have been identified. Here, we studied the role of isoform-rich dermokine – a wound- and tumor-regulated protein – in keratinocytes using a combin...
ORGANISM(S): Homo sapiens (Human) 
2026-04-09 | PXD074943 | Pride
ProteomicsMulit-omics analysis of keratinocytes reveals dermokine as regulator keratinocyte differentiation and adhesion - phosphoproteome and proteome
Impaired adhesion and differentiation of keratinocytes is a hallmark of several skin diseases, but only some of the factors that regulate these processes have been identified. Here, we studied the role of isoform-rich dermokine – a wound- and tumor-regulated protein – in keratinocytes using a combin...
ORGANISM(S): Homo sapiens (Human) 
2026-04-09 | PXD050151 | Pride
UnknownDermokine mutations contribute to epithelial-mesenchymal transition and advanced melanoma through ERK/MAPK pathways.
Not available
S-EPMC10335698 | biostudies-literature
UnknownDermokine contributes to epithelial-mesenchymal transition through increased activation of signal transducer and activator of transcription 3 in pancreatic cancer.
Not available
S-EPMC5665845 | biostudies-literature
ProteomicsCharacterizing dermokine isoforms in human epidermal equivalents
The epidermis provides a vital barrier between the human body and its external environment, playing critical roles in protection, water retention, and mechanical resistance. Dermokine, a secreted protein produced by suprabasal keratinocytes, is associated with epidermal stratification and terminal d...
ORGANISM(S): Homo Sapiens 
PXD055801 | panorama
ProteomicsPathological meprin a activity associated with degradation of dermokine drives a psoriasis-like skin phenotype in a novel genetic mouse model
Keratinocyte proliferation and differentiation is regulated via proteolytic networks. Dysregulation of proteases within these systems can cause hyperproliferative and inflammatory skin disorders. In healthy skin the metalloprotease meprin α is localized in the stratum basale, yet in wound healing ti...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-03 | PXD063928 | Pride
Degradomics Dia Mouse Psoriasis Tails Dermokine 
UnknownCrystal structures reveal the multi-ligand binding mechanism of Staphylococcus aureus ClfB.
Not available
S-EPMC3375286 | biostudies-literature
ProteomicsMMP10 degradomics in keratinocytes
Matrix metalloproteinases (MMPs) are important players in skin homeostasis, wound repair, and in the pathogenesis of skin cancer. One member – MMP10 – is specifically expressed in wound keratinocytes and in epithelial cancer cells, but its function is unclear and epidermal substrates are poorly char...
ORGANISM(S): Mus musculus (Mouse) 
2015-10-19 | PXD002474 | Pride
Itraq-tails Keratinocytes Mmp10 Skin Degradomics 
UnknownMatrix Metalloproteinase 10 Degradomics in Keratinocytes and Epidermal Tissue Identifies Bioactive Substrates With Pleiotropic Functions.
Not available
S-EPMC4762629 | biostudies-literature
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