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ProteomicsAggressive Gastric Cancer Overexpresses Trimmed N-Glycans and Exhibits Distinct Glycoproteome Signatures Predictive of Poor Prognosis
Gastric cancer poses a significant threat at advanced stages, with the identification of molecular signatures for prognosis and targeted treatment remaining crucial yet challenging. This study investigates the under-characterized gastric cancer glycocalyx, revealing glycan signatures linked to cance...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD060153 | Pride
Cancer glycobiology Glycoproteome Gastric cancer Glycome Precision oncology 
ProteomicsGlycoproteome of Human lung cancer cell by LC-MSMS
We demonstrate the utility of lectin-magnetic nanoprobe coupled with Orbitrap HCD-CID-MS/MS for complementary glycotope-specific enrichment and site-specific glycosylation analysis of the glycoproteome. Using non-small cell lung cancer (NSCLC) cells as model, this approach allowed us to compare the ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-25 | PXD010035 | Pride
Lc-msms Lung cancer cell Human Glycoproteom 
ProteomicsProbing the ovarian cancer O-glycoproteome by the Macrophage Galactose like C-type Lectin (MGL): dissecting novel patterns of immune recognition
Glycosylation, the posttranslational linking of sugar molecules to proteins, is notoriously altered during tumor transformation. More specifically in carcinomas, GalNAc-type O-glycosylation, is characterized by biosynthetically immature truncated glycans present on the cancer cell surface which prof...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD017510 | Pride
Ovarian cancer O-glycosylation Cancer immunotherapy Tn antigen Dcs Tumor biomarker 
ProteomicsIntegrated proteomic and N-glycoproteomic analyses of doxorubicin sensitive and resistant ovarian cancer cells reveal glycoprotein alteration in protein abundance and glycosylation
Ovarian cancer is one of the most common cancer among women in the world, and chemotherapy remains the principal treatment for patients. However, drug resistance is a major obstacle to the effective treatment of ovarian cancers and the underlying mechanism is not clear. An increased understanding of...
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD012655 | Pride
Multidrug resistance Ovarian cancer N-glycoproteome Silac Global proteome 
UnknownComparative studies of the proteome, glycoproteome, and N-glycome of clear cell renal cell carcinoma plasma before and after curative nephrectomy.
Not available
S-EPMC4227548 | biostudies-literature
UnknownThe Complexity and Dynamics of the Tissue Glycoproteome Associated With Prostate Cancer Progression.
Not available
S-EPMC8010466 | biostudies-literature
UnknownProbing the O-glycoproteome of gastric cancer cell lines for biomarker discovery.
Not available
S-EPMC4458724 | biostudies-literature
UnknownMining the O-mannose glycoproteome reveals cadherins as major O-mannosylated glycoproteins.
Not available
S-EPMC3876253 | biostudies-literature
UnknownMapping the O-glycoproteome using site-specific extraction of O-linked glycopeptides (EXoO).
Not available
S-EPMC6243375 | biostudies-literature
ProteomicsSialo-glycoproteome of Human lung cancer cell by LC-MSMS
Alterations in protein glycosylation, especially the terminal sialylation, are closely correlated with physiological and pathological regulation. Due to the low ionization efficiency of sialo-glycopeptides and frequently observed dissociation of sialic acid residues during mass spectrometry analysis...
ORGANISM(S): Homo sapiens (Human) 
2022-02-25 | PXD010456 | Pride
Sialo-glycoproteome Glycoproteome Human lung cancer 
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