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ProteomicsIn-depth proteomic profiling of gastric cancer tumor cells uncovers previously unidentified cancer testis antigens
In-depth proteomic profiling of gastric cancer tumor cells uncovers previously unidentified cancer testis antigens
ORGANISM(S): Homo sapiens (Human) 
2024-06-06 | PXD047203 | Pride
[rptep Ocs 
ProteomicsA library of novel Cancer Testis specific T cell receptors for T cell receptor gene therapy
Background Clinical success of T cell receptor (TCR) gene therapy has previously been demonstrated for NY-ESO-1 TCR gene therapy. To increase numbers of cancer patients that can be treated with TCR gene therapy we aimed to identify a novel set of high-affinity cancer specific TCRs targeting differen...
ORGANISM(S): Homo sapiens (Human) 
2023-01-23 | PXD038862 | Pride
T cell receptor Tcr gene therapy Mage Cd8+ t cells Cancer testis genes 
TranscriptomicsTranscription profiling of human testis, primary myeloma cell and normal tissue samples to identify novel cancer-testis genes
Cancer-testis (CT) antigens are attractive targets for immunotherapeutic strategies since they are aberrantly expressed in malignant cells and not, or in limited number, in somatic tissues, except germ cells. To identify novel CT genes in multiple myeloma, we used Affymetrix HG-U133 gene expression ...
ORGANISM(S): Homo sapiens 
2009-01-20 | E-MTAB-81 | biostudies-arrayexpress
TranscriptomicsTesticular germ cell tumor susceptibility genes from the consomic 129.MOLF-Chr19 mouse strain
Chromosome substitution strains (CSS or consomic strains) are useful for mapping phenotypes to chromosomes. However, huge efforts are needed to identify the gene(s) responsible for the phenotype in the complex context of the chromosome. Here, we report the identification of candidate disease genes...
ORGANISM(S): Mus musculus 
2009-01-13 | E-GEOD-14354 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human adult male germ cell tumours
Expression profiling of a panel of 101 adult male germ cell tumors and 5 normal testis specimens was performed on Affymetrix U133A and U133B microarrays. This data has been used to:; 1) generate a gene classifier that predicts histology (see PMID 15870693). 2) identify candidate target genes on 12p,...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3218 | biostudies-arrayexpress
UnknownComprehensive characterization of cancer-testis genes in testicular germ cell tumor.
Not available
S-EPMC6601584 | biostudies-literature
UnknownCombined RNA/tissue profiling identifies novel Cancer/testis genes.
Not available
S-EPMC8564638 | biostudies-literature
TranscriptomicsNext Generation Sequencing (RNAseq) of non-small cell lung cancer
Cancer testis antigens (CTAs) are of clinical interest as biomarkers and present valuable targets for immunotherapy. To comprehensively characterize the CTA landscape of non-small cell lung cancer (NSCLC), we compared RNAseq data of 199 NSCLC tissues to the normal transcriptome of 142 samples from 3...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-81089 | biostudies-arrayexpress
UnknownSystematic identification of genes with a cancer-testis expression pattern in 19 cancer types.
Not available
S-EPMC4737856 | biostudies-literature
TranscriptomicsAnalysis of HSF2 target genes using a global promoter ChIP-chip strategy on mouse wild-type testis
Mapping of in vivo targets for HSF2 by using mammalian tissue material in a global ChIP-chip promoter screen. Chromatin was isolated from three wild-type (WT) mouse testes, crosslinked and sonicated into fragments of 100-500 bp, and the quality of the DNA was controlled before the immunoprecipitatio...
ORGANISM(S): Mus musculus 
2008-08-05 | E-GEOD-9289 | biostudies-arrayexpress
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