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TranscriptomicsMiRNA expression analysis of cancer-associated fibroblasts (CAFs) and normal fibroblasts (NFs) in breast cancer
To identify miRNA differentially expressed in CAFs vs matched NFs and analyze the heterogeneity of miRNA expression profiles in the two kinds of cells, we established primary cultures of CAFs and paired NFs from six resected breast tumor tissue without any radiotherapy and chemotherapy treatment. Pa...
ORGANISM(S): Homo sapiens 
2012-09-28 | E-GEOD-37527 | biostudies-arrayexpress
MetabolomicsCancer-cell-secreted exosomal miR-105 promotes tumour growth through the Myc-dependent metabolic reprogramming of stromal cells
Cancer and other cells residing in the same niche engage various modes of interactions to synchronize and to buffer the negative effects of environmental changes. Extracellular miRNAs have been recently implicated in the intercellular crosstalk. Here we show a mechanistic model involving breast-canc...
2018-07-10 | MTBLS626 | MetaboLights
TranscriptomicsGenes activated by 5-aza-dC (DAC) in pancreatic (KPC-Brca1) cancer-associated fibroblasts (CAFs)
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that resists current treatments. To test epigenetic therapy against this cancer we used the DNA demethylating drug 5-aza-2’-deoxycytidine (DAC) in a KrasLSL-G12D; p53LSL-R270H/+; Pdx1-cre; Brca1flex2/flex2 (KPC-Brca1) mouse model of agg...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-42364 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cancer-associated fibroblasts treated with dasatinib
Effect of Dasatinib on primary cancer-associated fibroblasts from lung cancer specimens.
ORGANISM(S): Homo sapiens 
2011-01-12 | E-MEXP-2546 | biostudies-arrayexpress
TranscriptomicsIdentification of stromally expressed molecules in the prostate by Tag profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate
The stromal microenvironment plays key roles in prostate development and cancer. Cancer associated fibroblasts (CAFs) and other stromal cells stimulate tumourigenesis via several mechanisms including the expression of pro-tumourigenic factors. Mesenchyme (embryonic stroma) controls prostate organoge...
ORGANISM(S): Homo sapiens 
2011-10-22 | E-GEOD-25018 | biostudies-arrayexpress
TranscriptomicsExpression data from (mouse) normal lung fibroblasts and carcinoma-associated fibroblasts
Cancer-associated fibroblasts (CAFs) have been reported to support tumor progression by a variety of mechanisms. However, their role in the progression of non-small cell lung cancer (NSCLC) remains poorly defined. In addition, the extent to which specific proteins secreted by CAFs contribute directl...
ORGANISM(S): Mus musculus 
2013-07-10 | E-GEOD-48397 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling by array of human head and neck squamous cell carcinoma to study the correlation between galectin-1 upregulation and the presence of SMA positive cancer-associated fibroblasts
In this study, we set the presence of smooth muscle actin (SMA)-positive cancer-associated fibroblasts (CAFs) in relation to galectin-1 and its in vivo competitor (galectin-3). In squamous cell carcinomas of head and neck, upregulation of galectin-1 presence is highly significantly correlated to pre...
ORGANISM(S): Homo sapiens 
2012-11-01 | E-MTAB-850 | biostudies-arrayexpress
TranscriptomicsA cancer associated fibroblasts (CAFs) specific gene signature in high grade serous ovarian cancer
Ovarian cancer is the most lethal malignancy in the United States. In the year 2012, there will be an estimated 22,280 new cases and 15,500 deaths from ovarian cancer in the country (Siegel et al., 2012). While studies on ovarian cancer pathogenesis were mainly focused on the epithelial component of...
ORGANISM(S): Homo sapiens 
2014-09-11 | E-GEOD-40595 | biostudies-arrayexpress
TranscriptomicsPrognostic Gene Expression Signature of Carcinoma Associated Fibroblasts in Non-Small Cell Lung Cancer
The tumor microenvironment strongly influences cancer development, progression and metastasis. The role of carcinoma-associated fibroblasts (CAFs) in these processes and their clinical impact has not been studied systematically in non-small cell lung carcinoma (NSCLC). We established primary culture...
ORGANISM(S): Homo sapiens 
2011-04-08 | E-GEOD-22874 | biostudies-arrayexpress
TranscriptomicsPrognostic Gene Expression Signature of Carcinoma Associated Fibroblasts in Non-Small Cell Lung Cancer [methylation profiling]
The tumor microenvironment strongly influences cancer development, progression and metastasis. The role of carcinoma-associated fibroblasts (CAFs) in these processes and their clinical impact has not been studied systematically in non-small cell lung carcinoma (NSCLC). We established primary culture...
ORGANISM(S): Homo sapiens 
2011-04-08 | E-GEOD-27284 | biostudies-arrayexpress
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