Sort   by:  
 Page size 
MetabolomicsSingle-cell and spatial multi-omics reveal a recurrent multicellular niche at the tumor-stroma interface in multidrug resistance
Multi-drug resistance (MDR) is an almost inevitable end point of cancer therapy, driving rapid tumor progression, yet its evolutionary logic remains unclear because MDR tumors are rarely resected. Using paired therapy-naive and MDR melanoma specimens from a clinical trial, integrated with single-cel...
2027-08-13 | MTBLS15322 | MetaboLights
TranscriptomicsIdentification of stromally expressed molecules in the prostate by Tag profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate
The stromal microenvironment plays key roles in prostate development and cancer. Cancer associated fibroblasts (CAFs) and other stromal cells stimulate tumourigenesis via several mechanisms including the expression of pro-tumourigenic factors. Mesenchyme (embryonic stroma) controls prostate organoge...
ORGANISM(S): Homo sapiens 
2011-10-22 | E-GEOD-25018 | biostudies-arrayexpress
TranscriptomicsPrognostic Gene Expression Signature of Carcinoma Associated Fibroblasts in Non-Small Cell Lung Cancer [expression profiling_NSCLC stroma]
The tumor microenvironment strongly influences cancer development, progression and metastasis. The role of carcinoma-associated fibroblasts (CAFs) in these processes and their clinical impact has not been studied systematically in non-small cell lung carcinoma (NSCLC). We established primary culture...
ORGANISM(S): Homo sapiens 
2011-04-08 | E-GEOD-22863 | biostudies-arrayexpress
TranscriptomicsCells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations
Prostate cancer-associated stroma (CAS) plays an active role in malignant transformation, tumor progression, and metastasis. Molecular analyses of CAS have demonstrated significant changes in gene expression; however, conflicting evidence exists on whether genomic alterations in benign cells compris...
ORGANISM(S): Homo sapiens 
2016-02-12 | E-GEOD-76456 | biostudies-arrayexpress
MetabolomicsCancer-cell-secreted exosomal miR-105 promotes tumour growth through the Myc-dependent metabolic reprogramming of stromal cells
Cancer and other cells residing in the same niche engage various modes of interactions to synchronize and to buffer the negative effects of environmental changes. Extracellular miRNAs have been recently implicated in the intercellular crosstalk. Here we show a mechanistic model involving breast-canc...
2018-07-10 | MTBLS626 | MetaboLights
TranscriptomicsTranslating transcriptome of cancer cells in situ in mesenchymal-rich tumor microenvironment
A mesenchymal rich stroma such as cancer-associated fibroblasts (CAFs) in breast tumors favors the selection of cancer clones with enhanced bone metastatic ability. To determine the cancer cell transcriptomic response to the mesenchymal stroma, we supplemented experimental mammary tumours with or wi...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-GEOD-43306 | biostudies-arrayexpress
TranscriptomicsPrognostic Gene Expression Signature of Carcinoma Associated Fibroblasts in Non-Small Cell Lung Cancer
The tumor microenvironment strongly influences cancer development, progression and metastasis. The role of carcinoma-associated fibroblasts (CAFs) in these processes and their clinical impact has not been studied systematically in non-small cell lung carcinoma (NSCLC). We established primary culture...
ORGANISM(S): Homo sapiens 
2011-04-08 | E-GEOD-22874 | biostudies-arrayexpress
TranscriptomicsMolecular Signature of Pregnancy Associated Breast Cancer (PABC)
Malignant epithelia and tumor-associated stroma of PABC and Non-PABC were isolated by laser capture microdissection and gene expression profiled. Additionally, normal breast epithelia and stroma adjacent to the two tumor types were profiled. Lastly, subsets of previously identified E- and P-regulate...
ORGANISM(S): Homo sapiens 
2013-06-26 | E-GEOD-31192 | biostudies-arrayexpress
TranscriptomicsTranscriptome of the bone metastasis associated stroma
The reciprocal interaction between cancer cells and the tissue-specific stroma is critical for primary and metastatic tumor growth progression. Prostate cancer cells colonize preferentially bone (osteotropism), where they alter the physiological balance between osteoblast-mediated bone formation and...
ORGANISM(S): Mus musculus 
2014-12-09 | E-GEOD-22813 | biostudies-arrayexpress
TranscriptomicsPrognostic Gene Expression Signature of Carcinoma Associated Fibroblasts in Non-Small Cell Lung Cancer [methylation profiling]
The tumor microenvironment strongly influences cancer development, progression and metastasis. The role of carcinoma-associated fibroblasts (CAFs) in these processes and their clinical impact has not been studied systematically in non-small cell lung carcinoma (NSCLC). We established primary culture...
ORGANISM(S): Homo sapiens 
2011-04-08 | E-GEOD-27284 | biostudies-arrayexpress
Sort   by:  
 Page size