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MetabolomicsNon-targeted metabolomic profiling reveals Flo8-associated metabolic alterations in Candida glabrata
Flo8 is a transcriptional regulator involved in multiple physiological processes in Candida glabrata. To investigate the metabolic changes associated with Flo8, non-targeted metabolomic profiling was performed using the reference strain and a FLO8 deletion mutant. Intracellular metabolites were extr...
2026-08-19 | MTBLS15156 | MetaboLights
MetabolomicsMetabolic profiling of Candida clinical isolates of different species and infection sources

Candida species are the most common cause of opportunistic fungal infections. Rapid identification and novel approaches for the characterization of these fungi are of great interest to improve the diagnosis and the knowledge about their pathogenic properties. This study aimed to characte...

2024-07-09 | MTBLS1978 | MetaboLights
MetabolomicsOsh2 mediates Candida resistance to miltefosine by regulating zymosterol transport
Miltefosine has been identified for its antifungal properties, yet the mechanisms underlying its action and the development of resistance remain unclear. In this study, we induced drug resistance in various Candida species through concentration gradient exposure, successfully obtaining a miltefosine...
2025-07-03 | MTBLS12270 | MetaboLights
TranscriptomicsDefining the transcriptome landscape of Candida glabrata during pH change and nitrosative stress by RNA-Seq
The yeast Candida glabrata is one of the most important human fungal pathogens and has emerged as a leading cause of nosocomial bloodstream infections. Its resistance to many routinely used antimycotics and its close relationship to the model organism Saccharomyces cerevisiae make this fungus an int...
ORGANISM(S): Candida glabrata 
2015-01-27 | E-GEOD-61606 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of RPMI-grown and macrophage-internalized Candida glabrata wild-type, Cgrsc3-aM-bM-^HM-^F and Cgrtt109M-bM-^HM-^F cells.
To delineate the interaction of Candida glabrata with host immune cells, we performed genome-wide transcriptional profiling analysis on THP-1 macrophage-internalized wild-type and chromatin remodeling defective mutant (Cgrsc3-aM-bM-^HM-^F and Cgrtt109M-bM-^HM-^F) yeasts. Genes implicated in ergos...
ORGANISM(S): Candida glabrata 
2012-08-18 | E-GEOD-38953 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Candida glabrata after environmental stress
Characterization of Environmental Stress Response of Candida glabrata
ORGANISM(S): Candida glabrata 
2008-06-20 | E-MEXP-1427 | biostudies-arrayexpress
TranscriptomicsSelenite treatment of a Candida glabrata wild type strain
In the frame of a multispecies project, Candida glabrata cells were treated with 1 mM sodium selenite. Cells were collected 10, 20, 30, 40, 50, 60, 70 and 80 minutes after the treatment and their transcriptomes were compared to those of mock-treated cultures. Four independent biological replicates w...
ORGANISM(S): [Candida] glabrata 
2018-11-12 | E-MTAB-7023 | biostudies-arrayexpress
TranscriptomicsCandida glabrata transcription profile when grown under Niacin starvation or in human urine
The transcription profile of Candida glabrata grown under two different Niacin limitation conditions were determined. Condition 1 is comparing log phase C. glabrata cells (O.D. 0.5-0.6) grown in synthetic medium containing 0.016 uM versus 3.25 uM nicotinic acid (NA), a common form of Niacin. The NA ...
ORGANISM(S): Candida glabrata 
2010-06-05 | E-GEOD-6582 | biostudies-arrayexpress
MetabolomicsRapid Evaporative Ionisation Mass Spectrometry (REIMS) Provides Accurate Direct from Culture Species Identification within the Genus Candida
Members of the genus Candida, such as C. albicans and C. parapsilosis, are important human pathogens. Other members of this genus, previously believed to carry minimal disease risk, are increasingly recognised as important human pathogens, particularly because of variations in susceptibilities to wi...
2017-11-01 | MTBLS383 | MetaboLights
TranscriptomicsThe Candida glabrata transcription factor Stb5p is a negative regulator of ATP-binding cassette transporters
The opportunistic yeast pathogen Candida glabrata is recognized for its ability to acquire resistance during prolonged treatment with azole antifungals. Resistance to azoles is largely mediated by the transcription factor PDR1, resulting in the upregulation of ATP-binding cassette (ABC) transporter ...
ORGANISM(S): Candida glabrata 
2013-03-11 | E-GEOD-37071 | biostudies-arrayexpress
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