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Metabolomics1H NMR based urinary metabolites profiling dataset of canine mammary tumors

The identification of efficient and sensitive biomarkers for non-invasive tests is one of the major challenges in cancer diagnosis. To address this challenge, metabolomics is widely applied for identifying biomarkers that detects abnormal changes in cancer patients. Canine mammary tumors exhibit ...

2022-02-24 | MTBLS2550 | MetaboLights
TranscriptomicsGene expression profiles of canine osteosarcoma
Pulmonary metastasis continues to be the most common cause of death in osteosarcoma. Indeed, the 5-year survival for newly diagnosed osteosarcoma patients has not significantly changed in over 20 years. Further understanding of the mechanisms of metastasis and resistance for this aggressive pediatr...
ORGANISM(S): Canis lupus familiaris 
2010-05-08 | E-GEOD-16087 | biostudies-arrayexpress
TranscriptomicsComparative Transcriptional Analysis of Canine and Human Diffuse Large B cell Lymphoma (DLBCL). Molecular Signatures of NF-?B Pathway Activation and Sub-Classification of Canine DLBCL.
In this study, we present the first comparison of global transcriptional changes taking place in canine lymphoma and human diffuse large B-cell lymphoma (DLBCL), with particular reference to the nuclear factor-kappaB (NF-?B) pathway. Microarray data generated from lymph nodes diagnosed with canine D...
ORGANISM(S): Canis lupus familiaris 
2013-09-26 | E-GEOD-30881 | biostudies-arrayexpress
TranscriptomicsTranscriptional changes in demyelinating canine distemper virus encephalitis
Canine distemper virus (CDV)-induced demyelinating leukoencephalitis (CDV-DL) in dogs is a translational animal model for human demyelinating diseases such as multiple sclerosis. The aim of this study was to perform an assumption-free microarray analysis of gene expression in different subgroups of ...
ORGANISM(S): Canis familiaris 
2014-04-23 | E-MEXP-3917 | biostudies-arrayexpress
TranscriptomicsEffects of diet and age on canine cerebral cortex gene expression
Mechanisms contributing to age-related cognitive decline are poorly defined. Thus, we used canine microarrays to compare gene expression profiles of brain tissue from geriatric and young adult dogs. Cerebral cortex samples were collected from 6 geriatric (12 yr-old) and 6 young adult (1 yr-old) fe...
ORGANISM(S): Canis lupus familiaris 
2008-08-05 | E-GEOD-12328 | biostudies-arrayexpress
TranscriptomicsMetastatic Canine Mammary Carcinomas
[original title] Metastatic Canine Mammary Carcinomas can be Identified by a Gene Expression Profile that partly Overlaps with Human Breast Cancer Profiles. Introduction: Similar to human breast cancer mammary tumors of the female dog are commonly associated with a fatal outcome due to the develop...
ORGANISM(S): Canis lupus familiaris 
2010-12-01 | E-GEOD-20718 | biostudies-arrayexpress
ProteomicsProteomic Screening Identifies Novel Biomarkers and Mechanisms of Synovial Joint Disease in a Canine Model of Mucopolysaccharidosis I
Mucopolysaccharidosis I is a lysosomal storage disorder characterized by deficient alpha-L-iduronidase activity, leading to abnormal accumulation of glycosaminoglycans in cells and tissues. Synovial joint disease is prevalent and significantly reduces patient quality of life. There is a critical nee...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2024-05-22 | PXD037130 | Pride
Canine model Mucopolysaccharidosis Synovial fluid Serum Synovial joint disease 
TranscriptomicsCopy Number Abnormalities in Canine Mammary Cancers
Spontaneously occurring canine mammary cancer (MC) represents an excellent model of human breast cancer, but is greatly understudied. We performed high density arrays on 12 canine MC cases, including 7 simple carcinomas and four complex carcinomas. Simple carcinomas, which histologically match human...
ORGANISM(S): Canis lupus familiaris 
2014-09-07 | E-GEOD-54535 | biostudies-arrayexpress
TranscriptomicsProspective molecular profiling of canine cancers provides a clinically relevant comparative model for evaluating precision medicine (PMed) trials
Feasibility trial to examine the ability to conduct molecular guided therapy in a geographically distributed systems within strict time constraints Canine patients were enrolled across a broad panel of tumor types where tumor samples were acquired and processed to preserve RNA quality for genomic an...
ORGANISM(S): Canis lupus 
2014-04-28 | E-GEOD-51131 | biostudies-arrayexpress
TranscriptomicsMetastatic Cascade is Reflected in the Gene Expression of Metastatic Canine Mammary Carcinomas Similar to Human Breast Cancer
Proliferation, dedifferentiation, loss of cell-cell contacts and angiogenesis are among the first steps of the metastasis cascade. The complex molecular pathways associated with these events in canine mammary tumors are mostly unknown and the value of this spontaneous canine tumor as a comparative m...
ORGANISM(S): Canis lupus familiaris 
2010-12-01 | E-GEOD-22516 | biostudies-arrayexpress
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