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TranscriptomicsTranscription profiling of mouse Cannabinoid receptor double knockouts (Cnr1 -/- /Cnr2 -/-) in CHS model to investigate cutaneous contact hypersensitivity
We evaluated cutaneous contact hypersensitivity (CHS) in Cnr1-/-/Cnr2-/- animals using the obligate contact allergen 2,4-dinitrofluorobenzene (DNFB), which generates a specific cutaneous T-cell mediated allergic response upon repeated allergen contact. Allergic contact dermatitis affects about 5% of...
ORGANISM(S): Mus musculus 
2009-04-23 | E-GEOD-7694 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression profiling revealed peripheral effects of CB1 inverse agonists in improving insulin sensitivity and metabolic parameters
Inhibition of cannabinoid receptor 1 (CB1) has shown efficacy in reducing body weight and improving metabolic parameters, with the effects correlating with target engagement in the brain. Recently, the peripheral effects of inhibiting the CB1 receptor has been appreciated through studies in diet-ind...
ORGANISM(S): Mus musculus 
2010-06-21 | E-GEOD-21069 | biostudies-arrayexpress
TranscriptomicsCannabinoid Receptor 1 Dependent Effects of Isopropoyl dodeycl fluorophosphonate on Hepatic Gene Expression
We tested the effects of isopropoyl dodecyl fluorophosphonate (IDFP) (10 mg/kg, i.p.), a pharmacological inhibitor of endocannabinoid degradation, on hepatic gene expression in mice. To determine if increased cannabinoid receptor 1 signaling is responsible for IDFP induced effects a subset of mice w...
ORGANISM(S): Mus musculus 
2011-09-30 | E-GEOD-22949 | biostudies-arrayexpress
Proteomics: The effects of chronic morphine on the endogenous cannabinoid system in the ventral tegmental area
The United States is currently facing a severe opioid epidemic, therefore addressing how opioids induce rewarding behaviors could be key to a solution for this medical and societal crisis. Recently, the endogenous cannabinoid system has emerged as a hot topic in the study of opioid reward but relati...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-04-08 | PXD023096 | Pride
Ventral tegmental area Cannabinoid receptors Endocannabinoids Opioid Reward Endogenous cannabinoid system 
UnknownIn Vitro Signaling Properties of Cannabinoid and Orexin Receptors: How Orexin Receptors Influence Cannabinoid Receptor-Mediated Signaling.
Not available
S-EPMC11860274 | biostudies-literature
ProteomicsThe effect of cannabinoid receptor agonists on triple-negative breast cancer cell line (MDA-MB-231)
The endocannabinoid system (ECS) provides regulatory functions in several cellular and physiological processes. It has also been found to play a role in control of cancer development. Our group found that breast cancer cells responded to cannabinoid receptor (CB) agonist treatments. This leads the a...
ORGANISM(S): Homo sapiens (Human) 
2024-07-27 | PXD040666 | Pride
Breast cancer Triple-negative Proteomics Cannabinoid receptor agonists Human Endocannabinoid 
UnknownCannabinoid and Cannabinoid-Related Receptors in the Myenteric Plexus of the Porcine Ileum.
Not available
S-EPMC7912003 | biostudies-literature
UnknownCannabinoid Modulation of the Stressed Hippocampus.
Not available
S-EPMC5742214 | biostudies-literature
UnknownCannabinoid CB1 receptors regulate salivation.
Not available
S-EPMC9391487 | biostudies-literature
UnknownAbsence of Entourage: Terpenoids Commonly Found in Cannabis sativa Do Not Modulate the Functional Activity of Δ9-THC at Human CB1 and CB2 Receptors.
Not available
S-EPMC6757242 | biostudies-literature
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