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To study the relationship between microRNAs and μ-opioid receptor (MOR) signaling, we examined microRNA expression after chronic morphine or fentanyl treatment in rat primary hippocampal neurons and in mouse hippocampus. Mouse cerebellum region was also tested as a negative control to eliminate mic...
ORGANISM(S): Homo sapiens 
Opioids analgesics are frequently prescribed in the United States and worldwide. However, serious side effects such as addiction, immunosuppression and gastrointestinal symptoms limit their use. It has been recently demonstrated that morphine treatment results in significant disruption in gut barrie...
ORGANISM(S): Mus musculus 
The opioid receptors are important regulators of pain, reward, and addiction. Limited evidence suggests the mu and delta opioid receptors form a heterodimer (MDOR), which may act as a negative feedback brake on opioid-induced analgesia. However, evidence for the MDOR in vivo is indirect and limited,...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD022106 | Pride
The purpose of this study is to compare the effect of naloxegol versus the patient’s usual care in treating opioid-induced constipation, as well as the effect on the patient’s quality of life and how much pain is experienced. Also, the purpose of this study is to compare whether treatment with nalox...
Atherosclerosis is the most common cardiovascular disease, leading to complications such as myocardial infarction and stroke, the main but not the only causes of which are lipid accumulation and inflammation. In this study, we investigated whether opioid receptor blockade impacts factors involved in...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-27 | PXD064451 | Pride
Spectrotemporal profiling of ultrasonic vocalizations during neonatal opioid withdrawal reveals a kappa opioid receptor component in female mice
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