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TranscriptomicsExpression data from PDGF driven mouse tumors
Background Tumor heterogeneity is a major obstacle for finding effective treatment of Glioblastoma (GBM). Based on global expression analysis, GBM can be classified into distinct subtypes: Proneural, Neural, Classical and Mesenchymal. The signatures of these different tumor subtypes may reflect the ...
ORGANISM(S): Mus musculus 
2011-05-23 | E-GEOD-29458 | biostudies-arrayexpress
MetabolomicsDietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism

Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 (GPX-4), is generated directly from the sulfur-...

2023-01-11 | MTBLS5959 | MetaboLights
TranscriptomicsMRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma
We obtained radiographically-localized biopsies during glioma resection surgeries to sample the tumor core and margins from multiple glioma patients. We also procured fresh, non-neoplastic brain tissue specimens from multiple patients having procedures to relieve epilespy symptoms or to place shunts...
ORGANISM(S): Homo sapiens 
2014-07-22 | E-GEOD-59612 | biostudies-arrayexpress
ProteomicsDietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism
Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 (GPX-4), is generated directly from the sulfur-con...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-02 | PXD039476 | Pride
Metabolism Glioma Glutathione Ferroptosis Cysteine Methionine 
TranscriptomicsCell type-specific ribosome profiling in vivo.
We report cell-type specific ribosome profiling in a mouse glioma model. We report a strategy for cell-type specific ribosome profiling in vivo. Our strategy was applied to the characterization of a mouse glioma model.
ORGANISM(S): Mus musculus 
2014-08-25 | E-GEOD-51424 | biostudies-arrayexpress
TranscriptomicsExpression comparison of mutant EGFR-driven gliomas with relapse tumors upon mutant EGFR ablation
To determine the roles of oncogenic EGFR signaling in gliomagenesis and tumor maintenance, we generated a novel glioma mouse model driven by inducible expression of a mutant EGFR (EGFR*). Genetic suppression of EGFR* induction led to significant tumor regression and prolonged survival. But in spite ...
ORGANISM(S): Mus musculus 
2015-01-08 | E-GEOD-64751 | biostudies-arrayexpress
TranscriptomicsGenome-wide methylation analyses in glioblastoma multiforme (GBM)
Our main objective was to study genome-wide differential methylation in de novo glioblastoma multiforme (GBM, grade IV glioma). We evaluated CpG sites in gene promoters of 26,000+ genes using an array-based chip. We retrieved 54 GBM from biorepositories of two institutions(40 from Columbia Universit...
ORGANISM(S): Homo sapiens 
2013-10-18 | E-GEOD-50923 | biostudies-arrayexpress
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