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MetabolomicsFlavonoid pathway intermediates implicate UVR8 in functions beyond canonical UV-B signaling

Plants integrate light signals to regulate development and produce protective compounds such as flavonoids under excessive light stress. While these metabolites protect against light damage, their roles in modulating photoreceptor responses remain unclear. Here we show that naringenin chalcone (N...

2025-07-30 | MTBLS12792 | MetaboLights
MetabolomicsMedicarpin suppresses gastric cancer growth through modulation of mevalonate pathway-associated cholesterol biosynthesis
Background: Gastric cancer (GC) is an aggressive malignancy characterized by metabolic reprogramming, including dysregulated cholesterol biosynthesis. Medicarpin (Med), a natural isoflavan isolated from Radix Hedysari, has shown pharmacological potential; however, its anti-GC activity and metabolic ...
2026-10-02 | MTBLS15900 | MetaboLights
TranscriptomicsDistinctive microRNA signature of medulloblastomas associated with the WNT signaling pathway
Medulloblastoma is a malignant brain tumor that occurs predominantly in children. Current risk stratification based on the clinical parameters is inadequate for accurate prognostication. In order to get a better understanding of medulloblastoma biology, miRNA profiling of medulloblastomas was carrie...
ORGANISM(S): Homo sapiens 
2012-10-27 | E-GEOD-41842 | biostudies-arrayexpress
TranscriptomicsLS001A: Aging/Early Degeneration Of The Intervertebral Disc Involves Downregulation Of Canonical Wnt Signaling and Caveolin-1 expression
Objective: Aging and early degeneration of the intervertebral disc (IVD) involves the substition of notochordal cells (NCs) in the nucleus pulposus (NP) by chondrocyte-like cells (CLCs). This study investigated the gene expression profiles involved in this process using NP tissue from both non-chond...
ORGANISM(S): Canis lupus familiaris 
2013-01-31 | E-GEOD-35717 | biostudies-arrayexpress
ProteomicsWNT7 Promotes Proliferation of Pancreatic Progenitor Cells Differentiated from Human Pluripotent Stem Cells through Non-Canonical Wnt Signaling Pathway
A small molecule, AT7867, promotes proliferation of human pluripotent stem cell-derived pancreatic progenitor cells (PPCs), yet detailed mechanisms of its proliferative effect were not fully understood. Here, we performed cell-based siRNA screening on a subset of genes to reveal that WNT7B is a grow...
ORGANISM(S): Homo Sapiens (human) 
2022-03-27 | PXD018222 | JPOST Repository
ProteomicsWNT7 Promotes Proliferation of Pancreatic Progenitor Cells Differentiated from Human Pluripotent Stem Cells through Non-Canonical Wnt Signaling Pathway
A small molecule, AT7867, promotes proliferation of human pluripotent stem cell-derived pancreatic progenitor cells (PPCs), yet detailed mechanisms of its proliferative effect were not fully understood. Here, we performed cell-based siRNA screening on a subset of genes to reveal that WNT7B is a grow...
ORGANISM(S): Homo Sapiens (human) 
2021-07-01 | PXD018221 | JPOST Repository
TranscriptomicsHuman Wnt signaling pathway (Realtime qPCR array)
Human bone marrow mesenchymal stem cells (BMMSC) and human embryonic mesenchymal stem cells (ESMSC)were used. X-ray irradiation (2Gy) or 0Gy was delivered. After 4 hours, equal amount total RNA from each sample was extracted prior to gene expression analysis. After making cDNA, genes associated with...
ORGANISM(S): Homo sapiens 
2014-08-12 | E-GEOD-60310 | biostudies-arrayexpress
MetabolomicsTime-Restricted Feeding Orchestrates Astrocytic Metabolic Reprogramming via the Wnt Pathway to Alleviate Sevoflurane-Induced Neural Injury

Perioperative neurocognitive disorders (PND) pose a significant challenge for aging surgical patients, with sevoflurane anesthesia being an identified risk factor. Time-restricted feeding (TRF), a dietary regimen, shows promise in mitigating age-related cognitive decline, but its efficacy and mec...

2026-02-17 | MTBLS13891 | MetaboLights
OtherHuwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway.
Data from ProteomeXchange, PXD ID: PXD000781. File: KN_Ubi_endo_130528_minus_fr_65min_01.mzml. Published as part of Sci Signal. 2014 Mar 18;7(317):ra26 . From the Abstract: {{i}} In human embryonic kidney 293T cells, knockdown of the EEL-1 homolog Huwe1 enhanced the activity of a Wnt reporter in ce...
ORGANISM(S): Homo_sapiens_viruses, Human,one_off 
GPM32310000423 | GPMDB
Resource Reanalysis 
TranscriptomicsA supporting environment for hematopoietic stem/progenitor cells is maintained by canonical Wnt signaling
Considerable information has accumulated about components of bone marrow that regulate survival, self-renewal and differentiation of hematopoietic cells. We have now studied Wnt signaling in that context, assessing influences on human and murine hematopoiesis. Microarray, PCR and staining experime...
ORGANISM(S): Mus musculus 
2012-03-14 | E-GEOD-30791 | biostudies-arrayexpress
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