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ProteomicsMeasurement of site-specific H2O2-sensitivity and identification of sulfenic acid modification of CLOCK cysteines
In vitro H2O2-sensitivity of CLOCK cysteines was measured with a quantitative chemoproteomic approach termed as QTRP (Quantitative Thiol Reactivity Profiling) as previously reported. In brief, 5 μg of recombinant CLOCK proteins were reduced with 1 mM DTT for 30 min at room temperature. After reactio...
ORGANISM(S): Homo Sapiens Mus Musculus 
2019-08-31 | PXD015266 |
Proteomicsmouse liver concatenated tandem array of consensus TF response elements (catTFRE) with H2O2
a pull-down assay using a concatenated tandem array of consensus TF response elements (catTFRE) to trap the TFs expressed in mouse livers following treatment with or without H2O2
ORGANISM(S): Mus Musculus 
2019-08-31 | PXD015265 |
TranscriptomicsRNase-mediated protein footprint sequencing reveals protein-binding sites throughout the human transcriptome
RNAs are continuously associated with RNA-binding proteins (RBPs), and these interactions are necessary for many key cellular processes ranging from splicing to chromatin regulation. Although numerous approaches have been developed to map RNA-binding sites of individual RBPs, few methods exist that ...
ORGANISM(S): Homo sapiens 
2013-11-06 | E-GEOD-49309 | biostudies-arrayexpress
UnknownPrebiotic to Improve Calcium Absorption in Postmenopausal Women After Gastric Bypass: A Randomized Controlled Trial.
Not available
S-EPMC8947782 | biostudies-literature
TranscriptomicsPeripheral tissue instruction is the primary determinant of CD8+ T cell pathogenicity: transcription profiling by array of donor CD8+ effector T cells isolated from the secondary lymphoid organs, blood and GVHD-target organs at D+6 post-transplant (F>M model)
This study reports the evolution of the donor CD8 effector T cell transcriptomes at multiple sites and time points within the same host following allo-SCT. Donor derived CD8+ T cells were flow sorted from multiple organs in mice developing GVHD in two clinically relevant murine models of H-2b MHC-ma...
ORGANISM(S): Mus musculus 
2018-03-28 | E-MTAB-5379 | biostudies-arrayexpress
TranscriptomicsPeripheral tissue instruction is the primary determinant of CD8+ T cell pathogenicity: transcription profiling by array of donor CD8+ effector T cells isolated from the secondary lymphoid organs, blood and GVHD-target organs at D+6 post-transplant (B6>129 model)
This study reports the evolution of the donor CD8 effector T cell transcriptomes at multiple sites and time points within the same host following allo-SCT. Donor derived CD8+ T cells were flow sorted from multiple organs in mice developing GVHD in two clinically relevant murine models of H-2b MHC-ma...
ORGANISM(S): Mus musculus 
2017-01-16 | E-MTAB-5378 | biostudies-arrayexpress
UnknownRecommendations for Epstein-Barr virus-based screening for nasopharyngeal cancer in high- and intermediate-risk regions.
Not available
S-EPMC10086631 | biostudies-literature
TranscriptomicsFC-IBC-02: A New in vitro-in vivo Model of Triple Negative Inflammatory Breast Cancer
Inflammatory breast cancer (IBC) is the most aggressive type of advanced breast cancer and is associated with a poor prognosis. We have developed a new model of IBC derivated from the pleural effusion of a 49-year-old woman with metastatic secondary IBC. FC-IBC02 tumor cells were isolated from the p...
ORGANISM(S): Homo sapiens 
2012-09-20 | E-GEOD-40464 | biostudies-arrayexpress
TranscriptomicsClarion GO screen assay to assess gene expression responses of human mature adipocytes under control and IL-1B induced conditions in response to herbal extracts of Sage (S. offinicalis) and Chamomile (C. nobile).
Chronic inflammation plays a critical role in the initiation and development of various human illnesses. The use of steroidal anti-inflammatory drugs (SAIDs) or non-steroidal anti-inflammatory drugs (NSAIDs) is now much more frequent and presents a number of unwanted side effects. For example long-...
ORGANISM(S): Homo sapiens 
2020-10-05 | E-MTAB-9609 | biostudies-arrayexpress
GenomicsIntegrated approaches reveal determinants of genome-wide binding and function of the transcription factor Pho4
Binding of transcription factors to DNA is a key regulatory step in the control of gene expression. DNA sequences with high affinity for transcription factors occur more frequently in the genome than instances of genes bound or regulated by these factors. Although several mechanisms have been iden...
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-27 | E-GEOD-29506 | biostudies-arrayexpress
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