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MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
UnknownActivation of the STAT3 signaling pathway is associated with poor survival in diffuse large B-cell lymphoma treated with R-CHOP.
Not available
S-EPMC3871513 | biostudies-literature
TranscriptomicsLow oxygen responsive small RNAs in Arabidopsis
Low-oxygen stress associated with natural phenomena such as waterlogging, results in widespread transcriptome changes and a metabolic switch from aerobic respiration to anaerobic fermentation. High-throughput sequencing of small RNA libraries obtained from low-oxygen stressed and control root tissue...
ORGANISM(S): Arabidopsis thaliana 
2009-09-30 | E-GEOD-16971 | biostudies-arrayexpress
TranscriptomicsmRNA expression profiling in mouse bronchoalveolar stem cells (BASC)
We performed miRNA and mRNA profiling in BASC cells and c-Myc depleted BASC cells. We built potential miRNA-mRNA interaction networks specific to c-Myc regulation in BASCs Replicated profilling for both BASC cells and c-Myc depleted BASC cells.
ORGANISM(S): Mus musculus 
2012-01-26 | E-GEOD-30323 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profile in mouse bronchoalveolar stem cells (BASC)
We performed miRNA and mRNA profiling in BASC cells and c-Myc depleted BASC cells. We built potential miRNA-mRNA interaction networks specific to c-Myc regulation in BASCs Replicated profilling for both BASC cells and c-Myc depleted BASC cells.
ORGANISM(S): Mus musculus 
2012-01-26 | E-GEOD-30435 | biostudies-arrayexpress
UnknownLipoprotein-associated phospholipase A2: A paradigm for allosteric regulation by membranes.
Not available
S-EPMC8764669 | biostudies-literature
UnknownThe mechanism of allosteric regulation of calcium-independent phospholipase A<sub>2</sub> by ATP and calmodulin binding to the ankyrin domain.
Not available
S-EPMC11621833 | biostudies-literature
TranscriptomicsSost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner
WNT signaling is critical in most aspects of skeletal development and homeostasis, and antagonists of WNT signaling are emergning as key regulatory proteins with great promise as therapeutic agents for bone disorders. Until recently Sost and its paralog Sostdc1 have been described as growth factors ...
ORGANISM(S): Mus musculus 
2013-08-17 | E-GEOD-44325 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fibroblasts subjected to DNA damage reveals ATM-dependent regulation of gene expression
The relationships between profiles of global gene expression and DNA damage checkpoint functions were studied in cells from patients with ataxia telangiectasia (AT). Three telomerase-expressing AT fibroblast lines displayed the expected hypersensitivity to ionizing radiation (IR) and defects in DNA...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6971 | biostudies-arrayexpress
UnknownFluoroketone inhibition of Ca(2+)-independent phospholipase A2 through binding pocket association defined by hydrogen/deuterium exchange and molecular dynamics.
Not available
S-EPMC3561773 | biostudies-literature
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