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ProteomicsMelatonin Rescues Triclosan-Disrupted Porcine Oocyte Meiosis via Suppression of p53-Mediated Apoptosis
This study investigates the toxic effects of the environmental contaminant triclosan (TCS) on porcine oocyte meiosis and the protective role of melatonin (MT). Using an in vitro maturation model, TCS was found to impair polar body extrusion and cumulus expansion, while inducing oxidative stress, mit...
ORGANISM(S): Sus scrofa (Pig) 
2025-11-17 | PXD068303 | Pride
Porcine oocytes  melatonin  triclosan  apoptosis  p53 
UnknownOptimal target saturation of ligand-blocking anti-GITR antibody IBI37G5 dictates FcγR-independent GITR agonism and antitumor activity.
Not available
S-EPMC9245059 | biostudies-literature
TranscriptomicsEpithelial Expression of Toll-like Receptor 5 is Modulated in Healthy Smokers and Smokers with Chronic Obstructive Lung Disease
The toll-like receptors (TLRs) are important components of the respiratory epithelium host innate defense, enabling the airway surface to recognize and respond to a variety of insults in inhaled air. Based on the knowledge that smokers are more susceptible to pulmonary infection and the airway epith...
ORGANISM(S): Homo sapiens 
2012-10-03 | E-GEOD-30063 | biostudies-arrayexpress
TranscriptomicsSmoking-induced Wnt pathway downregulation
The Wnt pathway plays a central role in controlling differentiation of epithelial tissues; when Wnt is on, differentiation is suppressed, but when Wnt is off, differentiation is allowed to proceed. Based on this concept, we hypothesized that expression of key genes in the Wnt pathway are suppressed ...
ORGANISM(S): Homo sapiens 
2011-04-20 | E-GEOD-19407 | biostudies-arrayexpress
ProteomicsWanxi White Goose testis proteomics
The testicular tissue of Wanxi white geese was selected from three stages of the laying cycle (initial, peak and end stages), and the DIA strategy was used for proteomic sequencing.
ORGANISM(S): Anser Cygnoides 
PXD051168 |
ProteomicsHungarian white goose testis proteomics
The testicular tissue of Hungarian White Goose was selected from three stages of the laying cycle (initial, peak and end stages), and the DIA strategy was used for proteomic sequencing.
ORGANISM(S): Anser Cygnoides 
PXD051163 |
TranscriptomicsPersistence of Smoking-induced Dysregulation of Small Airway Epithelium miRNA Expression Despite Smoking Cessation
Rationale: Even after quitting smoking, the risk of the development of chronic obstructive pulmonary disease (COPD) and lung cancer remains significantly higher compared to never-smokers. Objectives: Based on the knowledge that COPD and most lung cancers start in the small airway epithelium (SAE), w...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-53519 | biostudies-arrayexpress
ProteomicsSS18 regulates pluripotent-somatic transition through phase separation
The transition from pluripotent to somatic states marks a critical event in mammalian development, but remains largely unresolved. Here we report the identification of SS18 as a regulator for pluripotent to somatic transition or PST by CRISPR-based whole genome screens. Mechanistically, SS18 forms m...
ORGANISM(S): Mus Musculus 
PXD026208 |
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