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Title: Prediction of cell cycle behaviour in response to DNA damage agents via transcriptomic approach
Description: Human lung adenocarcinoma A549 cells were treated with vehicle (DMSO) or Etoposide (ETOP, 10 M-BM-5M ), Benzo(a)pyrene (BaP, 25 M-BM-5M ), Cryptolepine ( CLP, 2.5 M-BM-5M) and 2...
ORGANISM(S): Homo sapiens 
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function is directly affected by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically...
2023-07-11 | MTBLS4766 | MetaboLights
The basic design of the experiment is as described in Fryer et al.(2000)Diabetes 49:1978, and is similar to proto-BAIR (EXP_BAIR_0603_02). H-2Kb muscle cells were treated with metformin (2mM) or insulin (100nM) for 0, 2 or 12 hours.
ORGANISM(S): Mus musculus 
Here we define key single-cell transcriptional alterations within cardiac non-myocytes, from ventricles of spontaneously type-2 diabetic (db/db) and control (db/h) mouse hearts ([B6.BKS(D)-Lepr/J], stock #000697). The cell preparation sequenced consisted of metabolically active, live and nucleat...
ORGANISM(S): Mus musculus 
Short-term fasting protects mice from lethal doses of chemotherapy through undetermined mechanisms. Herein, we demonstrate that fasting preserves small intestinal (SI) architecture by maintaining SI stem cell viability and SI barrier function following exposure to high-dose etoposide. Nearly all SI ...
ORGANISM(S): Mus musculus 
This experiment was used to determine the effect of a botanical insecticide upon gene expression profiles in Drosophila melanogaster. Adult female Drosophila (oregon-R strain) were treated with an ethylacetate extract of Piper nigrum (Piperaceae) seeds formulated in 99% ethanol. Treatment was topi...
ORGANISM(S): Drosophila melanogaster 
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