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ProteomicsCardiac Atrial Compartmentalisation Proteomics: A Modified Density Gradient Method to Analyse Endo-lysosomal Proteins
Evidence that lysosomes are important in cardiac physiology and pathology is now emerging. We describe a label-free method suitable for small cardiac tissue biopsies based on a density-separated fractionation protocol, which allows us to study endo-lysosomal (EL) proteins in guinea pig atria. The t...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2021-09-09 | PXD021277 | Pride
Cardiac Rab proteins Lysosome Guinea-pig Lysosome storage disease Atria 
ProteomicsCompartmentalisation proteomics revealed endolysosomal protein network changes in a goat model of atrial fibrillation
The emerging roles of endolysosomes (EL) in AF have yet to be discovered, especially how the EL contribute to the development of AF within a slow time frame. To identify the EL role in AF, we applied proteomics, transcriptomics, integrated analysis, electron tomography, western blotting and enzyme a...
ORGANISM(S): Capra hircus x Ovis aries 
2024-06-16 | PXD041056 | Pride
Endolysosomal protein Proteomics Atrial fibrillation Goat 
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