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ProteomicsCAR T cells inhibit B cell activating phosphorylation in their targets
Adoptive cell therapy, a subset of cancer immunotherapy, is collection of therapeutic approaches which aim to redirect the immune system by reprogramming patient T-cells to target antigenic molecules differentially and specifically expressed in certain cancers. One promising immunotherapy technique ...
ORGANISM(S): Homo sapiens (Human) 
2022-01-28 | PXD028109 | Pride
Cart signaling Phosphoproteomics Phosphotyrosine 
TranscriptomicsEgr2-dependent expression in T cell anergy
T cell anergy is one of the mechanisms contributing to peripheral tolerance, particularly in the context of progressively growing tumors and in tolerogenic treatments promoting allograft acceptance. We recently reported that early growth response gene 2 (Egr2) is a critical transcription factor for...
ORGANISM(S): Mus musculus 
2013-04-21 | E-GEOD-46242 | biostudies-arrayexpress
ProteomicsCSF1R-CAR T cells induce CSF1R signaling and promote target cell growth
Chimeric antigen receptor (CAR) T cells have revolutionized the landscape of cancer therapy, demonstrating unprecedented success in treating relapsed or refractory blood cancers. Previous studies of the mechanisms underlying the interactions and responses of CAR T cells and their targets have focuse...
ORGANISM(S): Homo sapiens (Human) 
2025-11-21 | PXD058576 | Pride
ProteomicsTarget antigen-displaying extracellular vesicles boost CAR T cell efficacy in neuroblastoma
GPC2 and GD2 are validated CAR T cell targets in neuroblastoma, but durable responses remain limited. We profiled the surfaceome of neuroblastoma-derived extracellular vesicles (EVs) and assessed their impact on CAR T cell function. Neuroblastoma EVs displayed GPC2 and GD2, with minimal PD-L1, and w...
ORGANISM(S): Homo sapiens (Human) 
2026-01-29 | PXD067632 | Pride
Neuroblastoma Car t cell targets Extracellular vesicles 
ModelsBarros2021 - CARTmath, Mathematical Model of CAR-T Immunotherapy in Raji Cell Line
A mathematical model (CART-math) studying the impact of CAR-T cells therapy on haematological cancer cell lines which in this case is RAJI.
2024-09-02 | BIOMD0000001020 | BioModels
ModelsBarros2021 - CARTmath, Mathematical Model of CAR-T Immunotherapy in HDLM-2 cell line
A mathematical model (CART-math) studying the impact of CAR-T cells therapy on haematological cancer cell line which in this case is HDLM-2.
2024-09-02 | BIOMD0000001019 | BioModels
TranscriptomicsTranscriptomic profiling of NK-92, CAR NK-92, and NR3C1-knockout CAR NK-92 cells following co-culture with CEACAM5⁺ A549 lung cancer cells
CEACAM5-specific CAR NK-92 cells were engineered to target CEACAM5-expressing lung tumor cells. To study their transcriptional response during tumor engagement, parental NK-92 cells, CEACAM5-CAR NK-92 cells, hydrocortisone-treated CAR NK-92 cells, NR3C1-knockout (cortisol-resistant) CAR NK-92 cells,...
ORGANISM(S): Homo sapiens 
2025-12-18 | E-MTAB-16373 | biostudies-arrayexpress
GenomicsHarnessing proximal T cell signaling molecules for enhanced CAR T cell activity
Harnessing proximal T cell signaling molecules for enhanced CAR T cell activity
PRJNA1126306 | ENA
UnknownGene Targets of CAR-T Cell Therapy for Glioblastoma.
Not available
S-EPMC10136592 | biostudies-literature
GenomicsEngineering Sonogenetic EchoBack-CAR T cells
Engineering Sonogenetic EchoBack-CAR T cells
PRJNA1222799 | ENA
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