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MetabolomicsProtein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the disco...

2023-08-07 | MTBLS7237 | MetaboLights
MetabolomicsLactobacillus plantarum MR1 alleviates high-carbohydrate diet-induced oxidative stress and liver lipid deposition via upregulating uridine synthesis
The overconsumption of carbohydrates induces oxidative stress and lipid accumulation in the liver, which can be alleviated by modulation of intestinal microbiota; however, the underlying mechanism remains unclear. Here, we demonstrated that a strain affiliated with Lactobacillus plantarum (de...
2024-01-16 | MTBLS4262 | MetaboLights
MetabolomicsDietary carbohydrate and protein levels affect the growth performance of juvenile peanut worm (Sipunculus nudus): an LC–MS-based metabolomics study
The peanut worm (Sipunculus nudus) is an economically important fishery resource in China. To determine how dietary carbohydrate and protein levels affects the growth performance of juvenile S. nudus and identify the mechanisms underlying observedpatterns, five isoenergetic and isolipidic diets with...
2021-07-16 | MTBLS2887 | MetaboLights
MetabolomicsImpacts of high-fat diet (HFD), high-carbohydrate diet (HCD) and high-fat-high-carbohydrate diet (HFHCD) on metabolites in a farmed cyprinid fish Megalobrama amblycephala.
Not available
ORGANISM(S): Megalobrama amblycephala 
ST000487 | MetabolomicsWorkbench
MetabolomicsIonic homeostasis, carbohydrate metabolism, and oxidative balance underlie wild soybean resistance to low potassium stress

The scarcity of potassium resources in farmland soils poses a major challenge to global food security. Wild soybean (Glycine soja), a valuable wild germplasm related to cultivated soybeans, is known for its high-stress resistance and adaptability. This study comprehensively compares two wild soyb...

2025-07-22 | MTBLS12462 | MetaboLights
MetabolomicsIonic homeostasis, carbohydrate metabolism, and oxidative balance underlie wild soybean resistance to low potassium stress

The scarcity of potassium resources in farmland soils poses a major challenge to global food security. Wild soybean (Glycine soja), a valuable wild germplasm related to cultivated soybeans, is known for its high-stress resistance and adaptability. This study comprehensively compares two wild soyb...

2026-04-12 | MTBLS14256 | MetaboLights
MetabolomicsMulti-omics and physiological analysis reveal the involvement of secondary metabolism and carbohydrate in drought regulation in alfalfa
Metabolite differential analysis indicates that genes involved in pathways such as secondary metabolism, carbohydrate, phenylpropanoid biosynthesis and flavonoid biosynthesis may regulate drought adaptation in alfalfa.
2025-09-23 | MTBLS9934 | MetaboLights
TranscriptomicsAnalysis of prebiotic carbohydrate utilization by Bifidobacterium lactis Bl-04 using differential transcriptomics
The global transcriptome of the Bifidobacterium animalis subsp. lactis Bl-04 was analyzed during exponential growth on 11 prebiotic carbohydrates and glucose to identify the specific gene cluster differentially upregulated in response to each carbohydrate. Affymetrix hybridization experiments were p...
ORGANISM(S): Bifidobacterium animalis subsp. lactis 
2013-10-23 | E-GEOD-41906 | biostudies-arrayexpress
MetabolomicsAcute response to a high-saturated, high-refined carbohydrate meal in healthy young men shows novel perturbation of multiple metabolic and defense pathways

Regular consumption of fat and refined carbohydrates induces metabolic stress, increasing chronic metabolic disease risk. In healthy volunteers, we characterised the response to a high-fat/high-carbohydrate meal (HFHCM), typical of an ultra-processed food, by proteomic and metabolomics analyses, ...

2026-04-02 | MTBLS10972 | MetaboLights
TranscriptomicsTranscription profiling of human blood cells after high protein and high carbohydrate breakfasts
Our aim was to evaluate the potential of gene expression profiling in blood in a human intervention study investigating the effect of two breakfasts with different macronutrient content on hormonal regulation of satiety. As dietary protein appears to be more satiating than dietary carbohydrate, we t...
ORGANISM(S): Homo sapiens 
2008-08-07 | E-TABM-271 | biostudies-arrayexpress
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