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TranscriptomicsEffects of Carbon Nanotubes Substrates on dendritic cells
To assess the effect of carbon nanotubes substrated on dendritic cell (DCs) properties, DCs were generated from human monocytes of healthy donors as previously described (Aldinucci A et al, 2010). In particular, isolated monocytes were cultured for 6 days in medium supplemented with GM-CSF (1000U/ml...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-MEXP-3560 | biostudies-arrayexpress
TranscriptomicsWhole Blood long non-coding RNA and mRNA Expression Profiles in Humans Exposed to Multi-walled Carbon Nanotubes
As the application of carbon nanotubes (CNT) in consumer products continues to rise, studies have expanded to determine the associated risks of exposure on human and environmental health. In particular, several lines of evidence indicate that exposure to multi-walled carbon nanotubes (MWCNT) could p...
ORGANISM(S): Homo sapiens 
2016-03-09 | E-GEOD-73830 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of mouse lung tissue exposed to multiwalled carbon nanotubes (Mitsui7)
There is great interest in substituting animal with in vitro experimentation in human health risk assessment, but there are rather few comparisons of in vitro and in vivo biological responses to engineered nanomaterials (ENM). We used high-content genomics tools, to compare in vivo pulmonary respon...
ORGANISM(S): Mus musculus 
2015-05-05 | E-GEOD-46998 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of cultured lung epithelial cells exposed to multiwalled carbon nanotubes (Mitsui7)
There is great interest in substituting animal with in vitro experimentation in human health risk assessment, but there are rather few comparisons of in vitro and in vivo biological responses to engineered nanomaterials (ENM). We used high-content genomics tools, to compare in vivo pulmonary respon...
ORGANISM(S): Mus musculus 
2015-05-05 | E-GEOD-46999 | biostudies-arrayexpress
TranscriptomicsChanges in cholesterol homeostasis and acute phase response following pulmonary exposure to multi-walled carbon nanotubes links carbon nanotube exposure to risk of cardiovascular disease
Adverse lung effects in rodents following pulmonary exposure to multi-walled carbon nanotubes (MWCNT) are well documented. However, systemic effects are less understood. Prospective epidemiological studies have shown increased cardiovascular disease risk after pulmonary exposure to airborne particle...
ORGANISM(S): Mus musculus 
2015-02-02 | E-GEOD-61366 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in rat alveolar macrophages exposure to single carbon nanotubes II
To further development of our gene expression approach to assess the effects of manufactured nanomaterials at the transcriptional level, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to distinguish characterization of physi...
ORGANISM(S): Rattus norvegicus 
2014-09-11 | E-GEOD-61319 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in human alveolar epithelial cell line exposure to single carbon nanotubes
To further development of our gene expression approach to assess the effects of manufactured nanomaterials at the molecular level, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to distinguish characterization of physico-che...
ORGANISM(S): Homo sapiens 
2012-09-25 | E-GEOD-41101 | biostudies-arrayexpress
TranscriptomicsWhole genome profile of SWNCT and MWCNT vs. asbestos subchronic exposures to human small airway epithelial cells
Recent in vivo studies reported that inhaled carbon nanotube distribute in the alveolar region resulting in an acute inflammation, progressive fibrotic response and particle accumulation at the bronchoalveolar junction with low clearance. With similar biopersistence and shape as asbestos, a known l...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-41178 | biostudies-arrayexpress
TranscriptomicsGene expression in spinal cord neurons grown on polyornithine or on carbon nanotube (CNT)-based substrates
Carbon nanotubes are cylindrically-shaped carbon nanostructures, made up of layers of graphene rolled onto themselves, with diameters similar to those of neuronal processes. In the last decade, CNT have been used as biocompatible growing substrates for neuronal attachment, differentiation and growth...
ORGANISM(S): Rattus norvegicus 
2013-08-05 | E-GEOD-27212 | biostudies-arrayexpress
GenomicsEffects of residual metals contained in single-wall carbon nanotubes on cellular response in rat alveolar macrophages and human alveolar epithelial cell line
Effects of residual metals contained in single-wall carbon nanotubes on cellular response in rat alveolar macrophages and human alveolar epithelial cell line
PRJNA297505 | ENA
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