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TranscriptomicsTranscriptional landscape modeling in Candida albicans defines a core filamentation response
comparison of. C.albicans grown on different pH and media over time
ORGANISM(S): Candida albicans 
2013-01-30 | E-MEXP-3675 | biostudies-arrayexpress
TranscriptomicsThe Two-component Signal Transduction System CopRS of Corynebacterium glutamicum is Required for Adaptation to Copper-excess Stress
Copper is an essential cofactor for many enzymes but at high concentrations it is toxic for the cell. Copper ion concentrations ≥50 µM inhibited growth of Corynebacterium glutamicum. The transcriptional response to 20 µM Cu2+ was studied using DNA microarrays and revealed 26 genes that showed a ≥3-f...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2011-09-04 | E-GEOD-27510 | biostudies-arrayexpress
TranscriptomicsEpidermal Growth Factor Receptor inhibition triggers Type 1 Interferon signature in human keratinocytes
The Epidermal Growth Factor Receptor (EGFR)/ligand system is centrally involved in multiple homeostatic functions of the epithelia. Epithelial cells are the primary targets of humanized antibodies and small molecule inhibitors against this system, whereby the constellation of skin-specific side effe...
ORGANISM(S): Homo sapiens 
2016-07-31 | E-GEOD-74407 | biostudies-arrayexpress
TranscriptomicsPyruvate carboxylase and carbon metabolism in Listeria monocytogenes
Transcriptional profile of wild type L. monocytogenes (EGDe) and a pycA mutant strain was compared on growth in BHI. The human pathogen L. monocytogenes is a facultatively intracellular bacterium that survives and replicates in the cytosol of many mammalian cells. The listerial metabolism, especia...
ORGANISM(S): Listeria monocytogenes 
2010-02-09 | E-GEOD-19014 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses to glucose in Saccharomyces cerevisiae strains lacking a functional protein kinase A
The pattern of gene transcription in Saccharomyces cerevisiae is strongly affected by the presence of glucose. An increased activity of protein kinase A (PKA), triggered by a rise in the intracellular concentration of cAMP, can account for many of the effects of glucose on transcription. To investig...
ORGANISM(S): Saccharomyces cerevisiae 
2011-08-08 | E-GEOD-27541 | biostudies-arrayexpress
TranscriptomicsComparative Genomics Reveals New Molecular targets for Accelerated Improvement of Erythromycin-producing Strains
Information about molecular mechanisms underlying improvement of antibiotic-producing microorganisms with traditional mutation and screening approach is largely missing. This information is essential to develop rational approaches to strain improvement. In this study by using comparative genomic ana...
ORGANISM(S): Saccharopolyspora erythraea 
2012-05-23 | E-GEOD-30600 | biostudies-arrayexpress
TranscriptomicsComparative genomics reveals new molecular targets for accelerated strain improvement of rifamycin B-producing strains
In the present study, we have used a genomic approach to understand how the classical mutate-and-screen method actually generated an improved rifamycin B producer. Compared with the reference strains Amycolatopsis mediterranei S699 (rifamycin B producer) and U32 (rifamycin SV producer), a total of 2...
ORGANISM(S): Amycolatopsis mediterranei S699 
2014-08-26 | E-GEOD-51015 | biostudies-arrayexpress
TranscriptomicsTemperature dependent Transcriptome of L. monocytogenes EGDe in minimal medium
Comparison of transcriptome of L. monocytogenes EGDe at 24M-BM-0C and 37M-BM-0C L. monocytogenes EGDe cells used in this study were grown either at 24M-BM-0C or 37M-BM-0C to an OD600 = 0.82-0.87 and the transcriptome of these two conditions was compared Six biologically independent cultures of each...
ORGANISM(S): Listeria monocytogenes EGD-e 
2014-05-23 | E-GEOD-51193 | biostudies-arrayexpress
TranscriptomicsHypoxia-inducible factor (Hif)-1 knockdown blocks tumor growth, myeloma-induced angiogenesis and bone destruction in vivo
In multiple myeloma (MM), hypoxia-inducible transcription factor-1 (HIF-1) is overexpressed in the MM cells of the hypoxic bone marrow (BM) microenvironment. Herein, we explored in MM cells the in vitro and in vivo effects of persistent HIF-1 inhibition by expression of a lentivirus shRNA pool on pr...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-GEOD-40326 | biostudies-arrayexpress
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