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MetabolomicsDietary Glutamine Supplementation Mitigates Age-Associated Cardiac Decline by Restricting H3K27me3

Epigenetic alterations are central drivers of cardiovascular aging, with histone modifications regulating gene expression through chromatin remodeling and changes in DNA accessibility. However, the mechanisms underlying these epigenetic shifts in the aging heart remain poorly defined. Here, we id...

2026-02-11 | MTBLS13890 | MetaboLights
MetabolomicsTen Mouse Organs Proteome and Metabolome Atlas from Adult to Aging

The complexity of the aging process, encompassing numerous organs and systems, poses a significant challenge in identifying and targeting key factors that drive age-related decline. The multi-organ synchronous molecular intricacies underlying natural aging remain elusive. Here we presented a data...

2025-08-29 | MTBLS10642 | MetaboLights
TranscriptomicsTranscription profiling of rat heart and adipose tissue response to aging and caloric restriction in
Sustained caloric restriction (CR) extends lifespan in animal models but the mechanism and primary tissue target(s) have not been identified. Gene expression changes with aging and CR were examined in both heart and subcutaneous white adipose tissue (WAT) of F344 male rats using Affymetrix® RAE 230...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-6718 | biostudies-arrayexpress
ProteomicsAcarbose improves late-life physical function in mice of both sexes, but rejuvenates cardiac structure and lipid profile in males only
With an expanding aging population burdened with comorbidities, there is considerable interest in treatments that optimize health in later life. Acarbose (ACA), a drug used clinically to treat Type 2 diabetes (T2DM) can extend mouse lifespan, with greater effect in males than in females. Utilizing a...
ORGANISM(S): Mus Musculus 
2021-03-03 | PXD017706 | panorama
TranscriptomicsLoss of Cardiac microRNA-Mediated Regulation Leads to Dilated Cardiomyopathy and Heart Failure.
RATIONALE: Heart failure is a deadly and devastating disease that places immense costs on an aging society. To develop therapies aimed at rescuing the failing heart, it is important to understand the molecular mechanisms underlying cardiomyocyte structure and function. OBJECTIVE: microRNAs are impor...
ORGANISM(S): Mus musculus 
2011-10-11 | E-GEOD-32881 | biostudies-arrayexpress
ProteomicsOverexpression of catalase delays age-related cardiac disease by preventing oxidative cysteine modifications
Reactive protein cysteine thiolates are instrumental in redox regulation. Aging associated to oxidative stress, can impair redox signaling by damaging essential cysteine thiolates. Our initial study found that cardiac-specific overexpression of catalase, can protect from oxidative stress and delay c...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-24 | PXD002479 | Pride
Metabolism Proteomics Reversible cysteine thiol oxidation Tmt Post-translational protein modifications Mass spectrometry Cardiac aging and disease 
TranscriptomicsThe Anti-Aging and Tumor Suppressor Protein Klotho Affects Signaling Pathwaysin a Human Oligodendroglioma Cell Line
Klotho functions as an aging suppressor, which, in mice, extends lifespan when overexpressed and accelerates development of aging-like phenotypes when disrupted. Klotho is mainly expressed in brain and kidney and is secreted into the serum and CSF. We have previously shown that Klotho is reduced in ...
ORGANISM(S): Homo sapiens 
2014-06-09 | E-GEOD-51536 | biostudies-arrayexpress
TranscriptomicsVascular niches as the primary hotspots for cardiac aging
Aging is a major, yet unmodifiable, risk factor for cardiovascular disease, leading to vascular alterations, increased cardiac fibrosis, and inflammation, all of which contribute to impaired cardiac function. To investigate the spatial impact of aging, we applied an integrative approach combining si...
ORGANISM(S): Mus musculus 
2025-10-31 | E-MTAB-14947 | biostudies-arrayexpress
MetabolomicsSIRT5 alleviate cardiomyocyte senescence in radiation-induced heart disease via desuccinylation of HADHB

SIRT5 deficiency caused widespread protein hypersuccinylation in cardiac tissue. Succinylation proteomic analysis revealed HADHB as the key SIRT5 target, with lysine 292 (K292) being the dominant succinylation site. Functional studies demonstrated that K292 succinylation impairs HADHB-mediated fa...

2026-03-15 | MTBLS14057 | MetaboLights
ProteomicsEffects of age and sex on protein abundance in the mouse heart
We compared protein abundance in the left and right ventricles of male and female C57BL6/J mice at 4 months and 20 months old. Frozen tissues were weighed, thawed, and cut into small pieces (2-3 mm3) on weigh boats on ice. Tissue pieces were transferred to 2.0 mL eppendorf tubes. Cold RIPA (Thermo #...
ORGANISM(S): Mus Musculus (mouse) 
2022-11-08 | PXD033719 | JPOST Repository
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