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MetabolomicsActivation of imprinted gene Pw1 promotes cardiac fibrosis after ischemic injury

Cardiac fibrosis, characterized by excessive extracellular matrix (ECM) deposition in the myocardium, is a critical target for heart disease treatments. Pw1 (paternally expressed gene 3) is an imprinted gene expressed from the paternally allele, and de novo purine biosynthesis (DNPB) is a crucial...

2024-12-03 | MTBLS11364 | MetaboLights
MetabolomicsGut Microbiota-Proline Axis Drives HFpEF Through Fibroblast Ferroptosis

Heart failure with preserved ejection fraction (HFpEF) is a complex cardiometabolic disorder closely associated with systemic metabolic dysregulation. In this study, plasma samples were collected from C57BL/6J mice subjected to a high-fat diet–induced HFpEF model, with or without intervention, an...

2026-01-16 | MTBLS13700 | MetaboLights
TranscriptomicsmicroRNA sequencing in rat cardiac fibroblasts and fibroblast-derived exosomes
We found that cardiac fibroblasts produce and secrete exosomes. miRNA profiling and TaqMan qRT-PCR experiments identified miR-21 expression to be higher in cardiac fibroblasts compared to those of miR-21*, whereas in exosomes miR-21* expression was higher compared to miR-21. The purpose of the stud...
ORGANISM(S): Rattus norvegicus 
2015-12-19 | E-GEOD-76175 | biostudies-arrayexpress
MetabolomicsMitochondrial Transplantation Ameliorates Doxorubicin-Induced Cardiac Dysfunction via Activating Glutamine Metabolism
Doxorubicin is a wildly used effective anticancer agent. However, doxorubicin use is also related to cardiotoxic side effect in some patients. Mitochondrial damage has been shown to be one of the pathogeneses of doxorubicin-induced myocardial injury. In this study, we test the hypothesis that mitoch...
2025-03-13 | MTBLS7989 | MetaboLights
TranscriptomicsGene expression profile of human cardiac fibroblasts (HCFs), induced cardiomyocytes (iCMs), and heart
Global gene expression profile of total 24460 probes in the iCMs. The gene expression shifts from a fibroblast state toward a cardiac-like phenotype by Gata4/Mef2c/Tbx5/Mesp1/Myocd (GMTMM) or GMTMM/miR-133 transduction at 7 days after transduction. MiR-133 silenced fibroblast signatures in parallel ...
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-56874 | biostudies-arrayexpress
ProteomicsHypoxia-induced changes in the fibroblast secretome, exosome, and whole-cell proteome using cultured, cardiac-derived cells isolated from neonatal mice
Dataset Pertaining to the proteome changes of the cardiac fibroblast in the whole cell, exosome, and soluble secretome.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-08-12 | MSV000080038 | MassIVE
Proteomicsintercardiac Phosphoproteome/proteome regulation of cardiomyocyte-fibroblast signaling
Secretome-mediated signaling from human iPSC-derived cardiomyocytes (TGF-beta induced dysfunction) to primary human cardiac fibroblasts was investigated to identify downstream regulators of fibrosis. Quantitative proteomic profiling revealed a dynamic reprogramming of fibroblast global proteome, wit...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-27 | MSV000092293 | MassIVE
TranscriptomicsCardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair
Cardiac fibroblasts are critical to proper heart function through multiple interactions with the myocardial compartment. Loosely defined based on their mesenchymal origin, capacity to adhere to plastic and to secrete extracellular matrix, cardiac fibroblasts have been largely neglected due to hetero...
ORGANISM(S): Mus musculus 
2014-05-20 | E-GEOD-50531 | biostudies-arrayexpress
ProteomicsCardiomyocytes regulate cardiac fibroblast activation and oxidative stress via CK2 signaling
Secretome-mediated signaling from human iPSC-derived cardiomyocytes (TGFβ induced dysfunction) to primary human cardiac fibroblasts was investigated to identify downstream regulators of fibrosis. Quantitative proteomic profiling revealed a dynamic reprogramming of fibroblast global proteome, with dy...
ORGANISM(S): Homo sapiens (Human) 
2025-02-11 | PXD038854 | Pride
Cardiac fibroblasts Cardiomyocytes Proteomics Ck2 Signaling 
TranscriptomicsTranscriptome modulation of ventricles, cardiomyocytes and cardiac fibroblasts during postnatal mouse development
During development the fetal heart undergoes a rapid and dramatic transition to adult function through transcriptional and post-transcriptional mechanisms, including alternative splicing (AS). We performed deep RNA-sequencing for high-resolution analysis of transcriptome changes during postnatal mou...
ORGANISM(S): Mus musculus 
2014-04-16 | E-GEOD-49906 | biostudies-arrayexpress
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