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MetabolomicsActivation of imprinted gene Pw1 promotes cardiac fibrosis after ischemic injury

Cardiac fibrosis, characterized by excessive extracellular matrix (ECM) deposition in the myocardium, is a critical target for heart disease treatments. Pw1 (paternally expressed gene 3) is an imprinted gene expressed from the paternally allele, and de novo purine biosynthesis (DNPB) is a crucial...

2024-12-03 | MTBLS11364 | MetaboLights
MetabolomicsSexual dimorphism in the fetal cardiac response to maternal nutrient restriction
Poor maternal nutrition causes intrauterine growth restriction (IUGR); however, its effects on fetal cardiac development are unclear. We have developed a baboon model of moderate maternal undernutrition, leading to IUGR. We hypothesized that the IUGR affects fetal cardiac structure and metabolism. S...
2018-04-30 | MTBLS426 | MetaboLights
MetabolomicsTargeting STK39 ameliorates cardiac remodeling by Improving Mitochondrial function through degradation of IFIT3

Pathological cardiac remodeling in response to sustained pressure overload is a pivotal process in the progression of heart failure (HF), yet the underlying molecular mechanisms remain incompletely understood, limiting therapeutic development. Here, we identify serine/threonine kinase 39 (STK39) ...

2026-09-28 | MTBLS15834 | MetaboLights
TranscriptomicsProtective effect of UDCA against IL-11- induced cardiac fibrosis is mediated by TGR5 signalling
1.1 Introduction Cardiac fibrosis occurs in a wide range of cardiac diseases and is characterised by the transdifferentiation of cardiac fibroblasts into myofibroblasts these cells produce large quantities of extracellular matrix, resulting in myocardial scar. The profibrotic process is m...
ORGANISM(S): Homo sapiens 
2024-11-30 | E-MTAB-14602 | biostudies-arrayexpress
ProteomicsTranscriptome and proteome profiling of activated cardiac fibroblasts supports target prioritization in cardiac fibrosis
Activated cardiac fibroblasts (CF) play a central role in cardiac fibrosis, a condition associated with most cardiovascular diseases. Conversion of quiescent into activated CF sustains heart integrity upon injury. However, permanence of CF in active state inflicts deleterious heart function effects....
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD034244 | Pride
Cardiac fibroblasts  cardiac fibrosis  myofibroblasts  transcriptomics  quantitative proteomics 
TranscriptomicsSingle cell RNA-Seq of the mouse heart in response to chronic stress
We characterized single-cell transcriptional profiles of heart ventricles of C57BL/6J female and male mice subjected to a chronic stress, two weeks of continuous administration of Angiotensin II. The cell preparation we sequenced consisted of metabolically active, nucleated non-myocyte cells which ...
ORGANISM(S): Mus musculus 
2020-11-24 | E-MTAB-8810 | biostudies-arrayexpress
TranscriptomicsSpatial transcriptomics (Visium, 10x Genomics) data for human Idiopathic Pulmonary Fibrosis (IPF) and control lung tissue
Visium (10x Genomics) spatially resolved transcriptomics data generated from normal and Idiopathic Pulmonary Fibrosis (IPF) lung parenchyma tissues collected from human donors. The fresh-frozen tissues that were analyzed were from four healthy control (HC) subjects and from four IPF patients. For ea...
ORGANISM(S): Homo sapiens 
2024-05-28 | E-MTAB-14121 | biostudies-arrayexpress
ProteomicsDefining the cardiac fibroblast secretome in the post-MI heart in vivo
Cardiac fibrosis is a common feature of ischemic heart disease and cardiac fibroblasts (CF) are key players in cardiac remodeling of the injured heart after myocardial infarction (MI). Fibrosis increases myocardial stiffness, thereby impairing cardiac function, which ultimately progresses to end-sta...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-25 | PXD053791 | Pride
Intercellular crosstalk Proteomics Turboid Myocardial infarction In vivo secretome 
TranscriptomicsGene expression profiles based on Pulmonary Artery Pressures in Pulmonary Fibrosis
Pulmonary Hypertension (PH) is a frequent complication of Pulmonary Fibrosis (PF). PH can be seen in PF in the abscence of hypoxemia, irrespective of the degree of fibrosis. At the same time, a consistent number of patients with advanced PF never develop PH. The pathogenesis of PH secondary to PF re...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-24988 | biostudies-arrayexpress
GenomicsConserved Transcriptional Circuits Regulate Cardiac Fibroblast-Mediated Fibrosis
Conserved Transcriptional Circuits Regulate Cardiac Fibroblast-Mediated Fibrosis
PRJNA1119184 | ENA
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