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MetabolomicsIntegrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency
Functional oncogenic links between ErbB2 and ERRα in HER2+ breast cancer patients support a therapeutic benefit of co-targeted therapies. However, ErbB2 and ERRα also play key roles in heart physiology, and this approach could pose a potential liability to cardiovascular health. Herein, using integr...
2022-09-20 | MTBLS795 | MetaboLights
MetabolomicsDistinct lipid signatures are identified in the plasma of rats with chronic inflammation induced by estradiol benzoate and sex hormones

INTRODUCTION: Prostatitis is likely to occur in younger or middle-aged men, while prostate cancer is likely to occur in older men. Although amino acids and lipids as biomarkers of prostate cancer have been examined using prostate cancer cell lines/tissues, no previous studies hav...

2020-11-04 | MTBLS2028 | MetaboLights
TranscriptomicsCardiac 12/15-lipoxygenase-induced inflammation is involved in heart failure
To identify a novel target for the treatment of heart failure, we examined gene expression in the failing heart. Among the genes analyzed, 12/15 lipoxygenase (12/15-LOX) was markedly up-regulated in heart failure. To determine whether increased expression of 12/15-LOX causes heart failure, we establ...
ORGANISM(S): Rattus norvegicus 
2009-06-06 | E-GEOD-16199 | biostudies-arrayexpress
MetabolomicsUntargeted Plasma Lipidomics Identifies Oxidative Stress and Inflammation Signatures Associated with Recurrent Leg Ulcer Status in Sickle Cell Disease

Leg ulcers are among the most burdensome complications of sickle cell disease (SCD), yet the molecular determinants underlying ulcer susceptibility and recurrence remain incompletely characterized. We performed untargeted plasma lipidomics by LC–MS in 129 individuals with SCD from the REDS-III Br...

2025-12-19 | MTBLS13538 | MetaboLights
TranscriptomicsBulk RNAseq of anti-PD1-induced cardiac dysfunction in C57BL/6J mice
C57BL6/J mice were treated with anti-PD-1 for 2 or 4 weeks, or with isotype control antibody. In echocardiography, cardiac dysfunction was seen both after 2 and 4 weeks, with decreased ejection fraction and left ventricular dilation. Bulk RNA sequencing of the hearts after treatment was performed to...
ORGANISM(S): Mus musculus 
2022-12-03 | E-MTAB-12388 | biostudies-arrayexpress
TranscriptomicsDifferential Gene Regulation during murine in vivo heart ischemia comparing wildtype and Per2 deficient mice
Disruption of peripheral circadian rhyme pathways dominantly leads to metabolic disorders. Studies on circadian rhythm proteins in the heart indicated a role for Clock or Per2 in cardiac metabolism. In fact, Per2-/- mice have larger infarct sizes with a deficient lactate production during myocardial...
ORGANISM(S): Mus musculus 
2013-08-21 | E-GEOD-45818 | biostudies-arrayexpress
GenomicsA cardiac fibroblast-enriched micropeptide regulates inflammation
A cardiac fibroblast-enriched micropeptide regulates inflammation
PRJNA1105958 | ENA
TranscriptomicsBone morphogenic protein-4 availability in the cardiac microenvironment controls myocardial inflammation and fibrosis - Single cell transcriptome analysis from healthy and inflamed murine hearts
Myocarditis is a heart condition that causes inflammation and results in the loss of heart muscle cells, often leading to fibrosis (scarring) of the heart tissue and heart failure. However, the molecular mechanisms underlying immune cell control and maintenance of tissue integrity in the inflamed ca...
ORGANISM(S): Mus musculus 
2024-01-16 | E-MTAB-12589 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat cardiac injury: a potential link to air pollution mortality?
Zinc (Zn) is a major elemental component of respirable ambient particulate matter (PM) detected often at alarming levels in urban air. Exposure to PM has been widely associated with increased cardiovascular morbidity and mortality, however, it is not known what components or sources of PM are causat...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-6541 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of cardiac valves from patients with bacterial infectious endocarditis
Transcriptional profiles of cardiac valves from patients with bacterial infectious endocarditis (3 infected with Streptococcus sp. and 2 infected with Staphylococcus aureus) were compared with uninfected cardiac valves (7 patients) from patients with hemodynamic disturbing events
ORGANISM(S): Homo sapiens 
2009-10-23 | E-MEXP-1334 | biostudies-arrayexpress
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