Sort   by:  
 Page size 
TranscriptomicsGene expression profiling of right atrium and left ventricle
A comparison of human cardiac gene expression profile in paired samples of right atrium and left ventricle extracted in vivo

ORGANISM(S): Homo sapiens 
2012-01-30 | E-MEXP-3396 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of heart left ventricles from 15 week old inbred COP, DA, and F1(COP x DA) offspring with respect to aerobic running capacity (low, high, and intermediate performers respectively)
We used high density oligonucleotide arrays to measure the relative expression levels of ~27,000 probe sets in the left ventricles of inbred rat strains; DA (high performing), Copenhagen (COP, low performing), as well as F1(COPxDA) rats bred from these tw
ORGANISM(S): Rattus norvegicus 
2007-09-13 | E-GEOD-1795 | biostudies-arrayexpress
MetabolomicsMyocardial-intrinsic defects underlie an Rbfox-mediated zebrafish model of hypoplastic left heart syndrome
Hypoplastic left heart syndrome (HLHS) is characterized by underdevelopment of left sided structures including the ventricle, valves, and aorta1. Although the mechanisms of disease pathogenesis remain elusive due to a paucity of candidate genes and animal models, prevailing paradigm suggests that HL...
2022-07-12 | MTBLS4176 | MetaboLights
TranscriptomicsCardiac phase-targeted dynamic load on left ventricle differentially regulates phase-sensitive gene expressions and pathway activation
Each heart was assigned to one of the following three conditions: phasic systolic overload (SO), phasic diastolic overload (DO), and no loading throughout the cardiac cycle (control; CN). We created SO by isovolumic contraction (peak systolic LVP > 170 mmHg) at a constant diastolic volume with end-d...
ORGANISM(S): Rattus norvegicus 
2013-02-07 | E-GEOD-44108 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of feft ventricle in three genetic rat models of hypertension
Left ventricle gene expression was analyzed in three models of hypertension in order to clarify the molecular mechanisms associated with left ventricular hypertrophy. Transgenic heterozygous TGR(mRen2)27 rats, overexpressing the mouse renin gene, and their littermate negative controls, spontaneously...
ORGANISM(S): Rattus norvegicus 
2006-08-31 | E-MEXP-357 | biostudies-arrayexpress
ProteomicsThe Calmodulin/Striatin Interaction is Enhanced in Diabetic Hearts and Defines Novel Signaling Clusters implicated in Cardiac Remodeling
Diabetic cardiomyopathy (DbCM) halts cardiac performance with a complex etiology, hence the absence of an effective therapy for this disease. Herein we decoded the proteins hub interconnected with Calmodulin (CaM), a striatin (STRN) binding protein, that plays a role in DbCM. Using CaM as a bait, we...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-06-15 | PXD069737 | Pride
Lc-msms Rat Tmt Cardiac left ventricles 
TranscriptomicsLeft-right transcriptomic differences in adult male mouse heart ventricles
Left and right heart ventricles of adult male mice were profiled to determine the differences in gene expression, control, coordination and signaling fabrics Two-sides (L= left, R = right) gene expression profiling experiment in adult mouse male (M) ventricles (V). 4 biological replicates: MVL1-4, M...
ORGANISM(S): Mus musculus 
2013-03-21 | E-GEOD-45348 | biostudies-arrayexpress
TranscriptomicsCardiac left ventricles of 12 week-old male C57BL/6J and C57BL/6J-chrY mice
We have reported previously that when chromosome Y (chrY) from the mouse strain C57BL/6J (abbreviated as B) was substituted for that of A/J mice (ChrY), cardiomyocytes from the resulting 'chromosome substitution' C57BL/6J-chrY strain (abbreviated as B.Y) were smaller than that of their C57BL/6...
ORGANISM(S): Mus musculus 
2009-05-01 | E-GEOD-15354 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human heart left ventricles
Left ventricle myocytes were prepared from patients with High or low ejection fraction, and subjected to mRNA profiling. Experiment Overall Design: Four HighEF and four heart failure specimens were analyzed.
ORGANISM(S): Homo sapiens 
2009-03-01 | E-GEOD-8331 | biostudies-arrayexpress
TranscriptomicsMutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy
Left ventricular noncompaction (LVNC) Causes prominent ventricular trabeculations and reduces cardiac systolic function. The clinical presentation of LVNC ranges from asymptomatic to heart failure. We show that germline mutations in human MIB1 (mindbomb homolog 1), which encodes an E3 ubiquitin liga...
ORGANISM(S): Mus musculus 
2015-08-10 | E-GEOD-71912 | biostudies-arrayexpress
Sort   by:  
 Page size