Sort   by:  
 Page size 
MetabolomicsCross-modal Integration of Metabolomics and Cardiac Functionality Captures Dynamic Metabotoxic Effects of Doxorubicin in Engineered Heart Tissues

Functional stem cell-derived heart models offer new avenues for preclinical, animal-free physiological assessment of drug cardiotoxicity. Yet, comprehensive molecular profiling in these models remains limited, leaving key metabolic drivers of cardiotoxicity unexplored.

Here, we leveraged an...

2025-12-07 | MTBLS13225 | MetaboLights
MetabolomicsNon-targeted metabolomics sequencing of cardiac tissue with or without high-valine diet
Non-targeted metabolomics revealed that a high-valine diet affected amino acid synthesis, biometabolism, and glycolipid metabolism in cardiac tissue from hypertensive animal model.
2026-09-26 | MTBLS15818 | MetaboLights
MetabolomicsMetabolomic data related to the alleviation of cardiac ischemia/reperfusion injury by NADPH derived from pentose phosphate pathway

Exercise promotes physiological cardiomyocyte growth and protects against ischemia/reperfusion (I/R) injury in the heart. The molecular mechanism by which exercise benefits cardiac metabolism and function remains largely unknown. Exercise (swimming or treadmill)-induced physiological hypertrophy ...

2026-05-14 | MTBLS14272 | MetaboLights
MetabolomicsTargeting Long-Chain Acylcarnitine Accumulation to Protect Cardiac Mitochondrial Homeostasis After Complete Revascularization

Approximately 20% of acute myocardial infarction patients with multivessel disease experience adverse outcomes after complete revascularization. We aim to investigate the underlying metabolic mechanism of ischemia-reperfusion injury responsible for abnormal hemodynamic stresses in high-risk patie...

2025-11-01 | MTBLS6651 | MetaboLights
MetabolomicsTargeted metabolomic profiling and machine learning-based prediction models for persistent atrial fibrillation: a multi-center observational study

Background. Atrial fibrillation (AF), the most common cardiac arrhythmia worldwide, carries a high risk of severe complications. Patients diagnosed with paroxysmal atrial fibrillation (PAF) may progress to persistent atrial fibrillation (PerAF) following a period. We aimed to identify metabo...

2026-07-03 | MTBLS13136 | MetaboLights
MetabolomicsGlycaemic variability identified as a critical determinant of myocyte dysfunction and risk for myocardial injury in preclinical models of diabetes
Heart disease is the leading cause of morbidity and mortality in individuals with diabetes, due largely to risks associated with ischaemic injuries such as myocardial infarction (MI). We use human population genetic data to demonstrate that current biomarkers of hyperglycaemia do not account for ris...
2026-02-06 | MTBLS11411 | MetaboLights
TranscriptomicsThe CNS-Heart Axis is a Source of Cardiac Dysfunction in Mouse Models of Huntington's Disease
Purpose: Transcriptome profiling (RNA-seq) to microarray to evaluate transcriptional changes in the heart of HD mouse models Methods: Heart mRNA profiles of 4-weeks-old wild-type (WT) and R6/2 transgenic; 15-weeks-old WT and R6/2 transgenic mice; 8-month-old WT and HdhQ150 knock-in mice; 22-month-ol...
ORGANISM(S): Mus musculus 
2014-07-15 | E-GEOD-58996 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of models of cardiac remodelling: myocardial infarction or transverse aortic constriction in left ventricle free wall and septum
We employed the Affymetrix GeneChip technology to evaluate the patterns of expression in two different in vivo models of cardiac remodeling and in two different regions (left ventricle free wall and septum) of the heart. Mice underwent transverse aortic constriction (TAC); myocardial infarction (MI)...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-415 | biostudies-arrayexpress
TranscriptomicsSRF Overexpression Leads to Altered Expression of MicroRNAs and Contributes to Cardiac Hypertrophy
The role of SRF in the regulation of microRNA expression and microRNA biogenesis in cardiac hypertrophy has not been well established. In this report, we employed a distinct transgenic mouse model to study the impact of SRF on cardiac microRNA expression and microRNA biogenesis. Cardiac-specific ove...
ORGANISM(S): Mus musculus 
2011-02-16 | E-GEOD-23044 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiling of myocardial infarction on a PI3K setting in mouse models
Cardiac hypertrophy can lead to heart failure, and is induced either by physiological stimuli eg postnatal development, chronic exrcise training or pathological stimuli eg pressure or volume overload. This data set looks at microRNA profiles in mouse models to examine whether phosphoinositide 3-kina...
ORGANISM(S): Mus musculus 
2010-05-06 | E-GEOD-14267 | biostudies-arrayexpress
Sort   by:  
 Page size