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ProteomicsCharacterisation of directed maturation in human cardiac organoids
Cardiac maturation is an important developmental phase where there are profound biological and functional changes after birth in mammals. Herein, we use our profiling of human heart maturation in vivo to identify key drivers of maturation in our human cardiac organoid (hCO) model. After screening of...
ORGANISM(S): Homo sapiens (Human) 
2025-04-17 | PXD059940 | Pride
Maturation Cardiac organoids 
ProteomicsProteomics of Extracellular Vesicles from hiPSC-Derived Cardiac Organoids
Human cardiac organoids were derived from hiPSCs using a regimen of small molecules and morphogens. Extracellular vesicles (cardEVs) were subsequently isolated from the conditioned medium via differential centrifugation. Finally, the proteomic cargo of cardEVs was characterized using LC-MS/MS and bi...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD072207 | Pride
Cardiod Extracellular vesicles Human Cardiac organoids 
ProteomicsCharacterisation of CASQ2 knockout cardiac organoid model
Cardiac maturation is an important developmental phase where there are profound biological and functional changes after birth in mammals. Herein, we use our profiling of human heart maturation in vivo to identify key drivers of maturation in our human cardiac organoid (hCO) model. In this dataset, w...
ORGANISM(S): Homo sapiens (Human) 
2025-04-17 | PXD055266 | Pride
Calsequesterin Crispr Cardiac organoids 
TranscriptomicsBulk RNA sequencing of cardiac organoids differentiated from hiPSC-derived cell lines with knockdown of factors involved in early cardiac specification
This dataset was generated to investigate the role of two DNA-binding factors, CTCF and GATA4, in early cardiac specification. Three WTC11-derived hiPSC lines were employed, each carrying a stably integrated shRNA construct. Two of the constructs specifically target CTCF and GATA4, while the third e...
ORGANISM(S): Homo sapiens 
2025-10-14 | E-MTAB-15710 | biostudies-arrayexpress
ProteomicsProteomics of vascularized cardiac organoids
Crosstalk between cardiac cells is critical during heart development but its role in organ maturation is still largely uncharacterised. Here, we show that endothelial cells increas the force of contraction and enhance the expression of mature sarcomeric proteins and extracellular matrix (ECM) compon...
ORGANISM(S): Homo sapiens (Human) 
2025-11-06 | PXD019266 | Pride
Cardioac organoids Endothelial cells 
ProteomicsCardiac organoids reveal mechanisms of human cardiogenesis
Self-organisation and coordinated morphogenesis of multiple cardiac lineages is essential for the development and function of the heart1-3. However, the absence of a human in vitro model that mimics the basic lineage architecture of the heart hinders research into developmental mechanisms and congen...
ORGANISM(S): Homo sapiens (Human) 
2021-05-18 | PXD018306 | Pride
Cardiac organoids Cardiac in vitro differentiation Human pluripotent stem cells 
GenomicsCardiac Organoids for Modeling Hypertrophic Cardiomyopathy
Cardiac Organoids for Modeling Hypertrophic Cardiomyopathy
PRJNA1094569 | ENA
TranscriptomicsSingle-cell RNA sequencing of hiPSC-derived cardiac organoids patterned toward chamber-specific fates (left ventricle, right ventricle, atrium)
Summary Single-cell RNA sequencing was performed on cardiac organoids differentiated from WTC11 hiPSCs (TTN-mEGFP) to investigate chamber-specific lineage commitment. Organoids were collected at day 7.5 of differentiation, using protocols designed to direct progenitors toward left ventricle, right v...
ORGANISM(S): Homo sapiens 
2025-10-14 | E-MTAB-15693 | biostudies-arrayexpress
GenomicsCardiac organoids reveal mechanisms of human cardiogenesis
Cardiac organoids reveal mechanisms of human cardiogenesis
PRJNA622830 | ENA
GenomicsCardiac organoids for Hypertophic cardiomyopathy
Cardiac organoids for Hypertophic cardiomyopathy
PRJNA1098220 | ENA
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