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TranscriptomicsmiRNA regulation in diabetes associated impaired wound healing
Circulating miRNAs constitute a novel class of disease biomarkers, which are altered in diabetes but the effect of diabetes associated inflammation as seen in chronic wounds is unknown. We here compared the miRNA pattern in diabetic patients in presence or absence of chronic wound with PAD. The clin...
ORGANISM(S): Homo sapiens 
2015-06-09 | E-GEOD-49885 | biostudies-arrayexpress
TranscriptomicsIdentification and Functional Analysis of Healing Regulators in Drosophila
Wound healing is an essential homeostatic mechanism that maintains the epithelial barrier integrity after tissue damage. Although we know the main events participating in the healing of a wound, many of the underlying molecular mechanisms remain unclear. Genetically amenable systems, such as wound h...
ORGANISM(S): Drosophila melanogaster 
2015-04-13 | E-GEOD-62863 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary fibroblasts from 10 anatomic sites expanded in DMEM supplemented with 10% fetal calf serum, penicillin/streptomycin, and glutamine (Tumor as Wound)
Cancer invasion and metastasis have been likened to wound healing gone awry. Despite striking parallels in cellular behavior between cancer progression and wound healing, the molecular relationships between these two processes, and their prognostic implications, are unclear. Here, based on gene exp...
ORGANISM(S): Homo sapiens 
2005-10-31 | E-SMDB-2287 | biostudies-arrayexpress
TranscriptomicsThe genetics of wound healing in tympanic membranes in rats
The aim of this study was to identify the genes differentially expressed between timepoints in the week following tympanic membrane perforation in rats. Tissue from 240 individual rats was used in this study following random allocation into timepoint groups to be sacrificed over 7 days. An Agilent o...
ORGANISM(S): Rattus norvegicus 
2010-08-18 | E-GEOD-17698 | biostudies-arrayexpress
GenomicsSipa1 Drives the Inflammatory Signature of Cardiac Fibroblasts and Aggravates Wound Healing Response After Myocardial Infarction
Sipa1 Drives the Inflammatory Signature of Cardiac Fibroblasts and Aggravates Wound Healing Response After Myocardial Infarction
PRJNA1256293 | ENA
GenomicsPost-transcriptional Fibroblast Fate Switching By MBNL1 Regulates Fibrotic and Myocardial Remodeling During Cardiac Wound Healing
Post-transcriptional Fibroblast Fate Switching By MBNL1 Regulates Fibrotic and Myocardial Remodeling During Cardiac Wound Healing
PRJNA795776 | ENA
ProteomicsExtracellular Matrix Protein 1 as a critical mediator of inflammation-to-fibrosis crosstalk in wound healing after myocardial infarction
Aims and introduction: Cardiac fibrosis is the hallmark of cardiac disease, particularly myocardial infarction (MI), and is one of the most prevalent causes of heart failure. MI is intricately linked to inflammation, extracellular matrix (ECM) remodelling, and cardiac fibrosis, however the mechanism...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD027626 | Pride
Ecm1 Adult human cardiac fibroblast (hucfb) cell line Human Cardiac wound healing Extracellular matrix Heart failure (hf) 
TranscriptomicsA Time Course Analysis of the Effects of Marinobufagenin in Human Dermal Fibroblasts
Gene expression profiling of the effets of marinobufagenin in a time-course study (0, 0.25, 0.5, 0.75, 1, 2, 3, 6, 9, 12, 15, and 24 hrs) to examine the temporal changes in gene expression in a human dermal fibroblast cell line. Keywords: Time course Cells were treated with 10 nM of marinobufagenin ...
ORGANISM(S): Homo sapiens 
2007-12-06 | E-GEOD-9806 | biostudies-arrayexpress
GenomicsSplenic CD169+Tim4+ Marginal Metallophilic Macrophages Are Essential for Wound Healing After Myocardial Infarction
Splenic CD169+Tim4+ Marginal Metallophilic Macrophages Are Essential for Wound Healing After Myocardial Infarction
PRJNA1225298 | ENA
TranscriptomicsSipa1 Drives the Inflammatory Signature of Cardiac Fibroblasts and Aggravates Wound Healing Response After Myocardial Infarction
Signal-induced proliferation-associated gene 1 (Sipa1) is known as a specific Rap1 GTPase-activating protein that negatively regulates Rap1 signaling. Although Sipa1 has been extensively studied in cancer research, its role in the wound healing response after myocardial infarction (MI) remains unexp...
ORGANISM(S): Mus musculus 
2025-08-01 | GSE295755 | GEO
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