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MetabolomicsECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction is critically dependent on cell-cell communication mediated by exosomes, small ves...

2020-10-07 | MTBLS1969 | MetaboLights
MetabolomicsECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction is critically dependent on cell-cell communication mediated by exosomes, small ves...

2020-10-07 | MTBLS1977 | MetaboLights
UnknownFERARI and cargo adaptors coordinate cargo flow through sorting endosomes.
Not available
S-EPMC9359993 | biostudies-literature
ProteomicsMGAT3 and MGAT5 overexpression alters the protein cargo of extracellular vesicles released by metastatic melanoma cells
Extracellular vesicles (EVs) are potential non-invasive diagnostic, prognostic, and therapeutic tools. Additionally, they are important contributors to tumorigenesis. Glycosylation has been found to modulate the composition of the EV proteome, and increased amounts of beta 1,6-branched N-glycans, sy...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-08 | MSV000096340 | MassIVE
ProteomicsPhosphorylation of SNX17 impedes activation of Retriever-mediated sorting
Sorting nexin 17 (SNX17) functions as cargo receptor on endosomal membranes that enables the recycling of numerous membrane cargo proteins by binding to the Retriever complex. Yet, little is known how SNX17 activity or its membrane recruitment is regulated. Here, we report that phosphorylation of SN...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-06-30 | PXD061808 | Pride
Endosome Intracellular trafficking Sorting nexin Retriever Phosphorylation Integrin Phox domain 
ProteomicsStiffness Programs WDR44 Phosphorylation to Gate Cargo Sorting into Migrasomes
Cells release extracellular vesicles (EVs) for intercellular communication, homeostasis, and microenvironment remodeling, yet how physiological matrix stiffness controls EV cargo sorting remains unclear. Here we show that stiffness programs a cargo-selective sorting pathway in migrasomes, where matr...
ORGANISM(S): Mus Musculus 
PXD083164 |
UnknownRab4A organizes endosomal domains for sorting cargo to lysosome-related organelles.
Not available
S-EPMC6151265 | biostudies-literature
UnknownDimeric sorting code for concentrative cargo selection by the COPII coat.
Not available
S-EPMC5889621 | biostudies-literature
UnknownESCRT ubiquitin-binding domains function cooperatively during MVB cargo sorting.
Not available
S-EPMC2700381 | biostudies-literature
UnknownA family of tetraspans organizes cargo for sorting into multivesicular bodies.
Not available
S-EPMC4421094 | biostudies-literature
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